Skip to main content

Dr. Todd Hoare

Associate Professor

Department of Chemical Engineering

Associate Chair (Graduate)

Department of Chemical Engineering

Expertise:
nanotechnology, interfacial engineering, biomaterials engineering, polymer science, pharmaceutical science
Areas of Specialization:
Research Clusters:

Overview

The Hoare lab works at the interface of polymer science, physical chemistry, and biology, aiming to design novel materials with “smart” properties precisely tuned to the environment and application in which the material is to be used. Our main expertise lies in the rational design of “smart” hydrogel-based materials on different length scales (i.e. bulk hydrogels, microgels, and nanogels) based on a fundamental understanding of the structure-property relationships in such materials. To achieve this understanding, we apply both the analytical tools of physical chemistry and the mathematical modeling tools of chemical engineering to predict microstructures prior to synthesis and then characterize (and optimize) the realized microstructures for specific applications. While most of our target applications lie within biomedical engineering (drug delivery, cell encapsulation, biomedical devices, biosensors, and tissue engineering), we also apply our engineered hydrogels in food, nutraceutical, agricultural, and environmental applications.

Education

  • B.Sc. (Eng), Engineering Chemistry, Queen’s University (2001)
  • Ph.D., Chemical Engineering, McMaster University (2006)
  • Post-Doctoral Fellow, Langer Lab, Massachusetts Institute of Technology (2006-2008)

Biography

Todd Hoare received a B.Sc. (Eng.) in Engineering Chemistry from Queen’s University in 2001 and a Ph.D. in Chemical Engineering from McMaster in 2006. He returned to McMaster in 2008 to join the faculty after a two-year NSERC (Natural Sciences and Engineering Research Council of Canada)-sponsored post-doctoral fellowship in Robert Langer’s laboratory at the Massachusetts Institute of Technology.  Dr. Hoare’s work has been profiled by Popular Science, Maclean’s, and BBC for its potential in solving clinical challenges through innovative smart materials design. He has won an NSERC Innovation Challenge award recognizing the novelty of his research. He also received the 2016 Early Career Investigator Award from the Canadian Biomaterials Society, an Early Researcher Award and the 2009 John Charles Polanyi Prize in Chemistry from the Government of Ontario recognizing his accomplishments in his early career as a researcher and was a finalist for the 2012 President's Award for Graduate Supervision.  Dr. Hoare is currently the Associate Editor of Chemical Engineering Journal and is a member of the Editorial Advisory Board of Colloid and Polymer Science. He also teaches two undergraduate courses and two graduate courses in the Department of Chemical Engineering and School of Biomedical Engineering at McMaster.

Publications

Recent

  • De France, K.J.; Yager, K.G.; Chan, K.J.W.; Cranston, E.D., Hoare, T.  “Injectable Anisotropic Nanocomposite Hydrogels for In Situ Orientation of Myotube Growth”.  Nano Letters2017, DOI: 10.1021/acs.nanolett.7b03600.
  • De France, K.J.; Xu, F.; Hoare, T.  “Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities”.  Advanced Healthcare Materials2017, in press [invited review]
  • Bakaic, E.; Smeets, N.M.B.; Barrigar, O.; Alsop, R.; Rheinstädter. M.C.; Hoare, T.  “pH-Ionizable In situ-Gelling Poly(Oligo ethylene glycol methacrylate)-Based Hydrogels: The Role of Internal Network Structures in Controlling Macroscopic Properties”.  Macromolecules2017, DOI: 10.1021/acs.macromol.7b01505.
  • Bakaic, E.; Smeets, N.M.B.; Badv, M.; Dodd, M.; Barrigar, O.; Siebers, E.; Lawlor, M.; Sheardown, H.; Hoare, T.  “Injectable and Degradable Poly(Oligoethylene glycol methacrylate) Hydrogels With Tunable Charge Densities as Adhesive Peptide-Free Cell Scaffolds”.  ACS Biomaterials Science & Engineering2017, DOI: 10.1021/acsbiomaterials.7b00397.
  • De France, K.J.; Hoare, T.; Cranston, E.D.  “A Review of Nanocellulose-Containing Hydrogels and Aerogels”.  Chemistry of Materials201729, 4609–4631 [invited review] [cover article]
  • Yu, C.; Kornmuller, A.; Brown, C.; Hoare, T.; Flynn, L.E.  “Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion”.  Biomaterials, 2017,120, 66-80.
  • Katare, Y.K.; Piazza, J.E.; Bhandari, J.; Daya, R.; Akilan, K.; Simpson, M.J.; Hoare, T.; Mishra, R.K.  “Intranasal Delivery of Antipsychotic Drugs”.  Schizophrenia Research2017184, 2-13.
  • Zhang, J.; Muirhead, B.; Dodd, M.; Liu, L.; Mangiacotte, N.; Xu, F.; Hoare, T.; Sheardown, H.  “An Injectable Hydrogel Prepared Using a PEG/Vitamin E Copolymer Facilitating Aqueous-Driven Gelation”. Biomacromolecules201617, 3648-3658. 
  •  Urosev, I.; Bakaic, E.; Alsop, R.J.; Rheinstadter, M.C.; Hoare, T.  “Tuning the Properties of Injectable Poly(Oligoethylene Glycol Methacrylate) Hydrogels by Controlling Precursor Polymer Molecular Weight”. Journal of Materials Chemistry B2016, 4, 6541-6551.
  • Jamard, M.; Hoare, T.; Sheardown, H.  “Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery”.  Drug Delivery and Translational Research20166, 648-659. 
  • Deng, X.; Korogiannaki, M.; Rastegari, B.; Zhang, J.; Chen, M.; Fu, Q.; Sheardown, H.; Filipe, C.D.M.; Hoare, T.  “’Click’ Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower Protein Adsorption”.  ACS Applied Materials and Interfaces20168, 22064–22073. 
  • De France, K.J.; Yager, K.G.; Hoare, T.; Cranston, E.D.  “Cooperative Ordering and Kinetics of Cellulose Nanocrystal Alignment in a Magnetic Field”.  Langmuir201632, 7564-7571.
  • Chau, M.*; De France, K.*; Kopera, B.; Machado, V.; Rosenfeldt, S.; Reyes, L.; Chan, K.; Forster, S.; Cranston, E.; Hoare, T.; Kumacheva, E.  “Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties”.  Chemistry of Materials201628, 3406-3415   * = co-first authors
  • Hodgson, S.; Bakaic, E.; Stewart, S.A.; Hoare, T.; Adronov, A.  “Properties of Poly(Ethylene Glycol) Hydrogels Crosslinked via Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC)”.  Biomacromolecules2016,17, 1093-1100.
  • Maitland, D.M.; Campbell, S.B.; Chen, J.Hoare, T.  “Controlling the Resolution and Duration of Pulsatile Release from Injectable Magnetic ‘Plum-Pudding’ Nanocomposite Hydrogels”.  RSC Advances20166, 15770-15781.
  • De France, K.J.; Chan K.J.W.; Cranston, E.D., Hoare, T.  “Enhanced mechanical properties in cellulose nanocrystal-poly(oligo ethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linking”.  Biomacromolecules201617, 649-660. 
  • Deng, X.; Chen, M.; Fu, Q.; Smeets, N.M.B.; Xu, F.; Zhang, Z.; Filipe, C.D.M.; Hoare, T.  “A highly-sensitive immunosorbent assay based on biotinylated graphene oxide and the quartz crystal microbalance”.  ACS Applied Materials and Interfaces20168, 1893-1902.
  • Grenga, P.; Nethercott, M.; Mateo, A.; Patenaude, M.; Hoare, T.; Weliky, D.; Priefer, R.  “Thermal and Spectral Analysis of Novel Amide-Tethered Polymers from Polyallylamine”.  Australian Journal of Chemistry,201669, 458-466. 
  • Xu, F.; Sheardown, H.; Hoare, T.  “Reactive Electrospinning of Degradable Poly(oligoethylene glycol methacrylate)-Based Nanofibrous Hydrogel Networks”.  Chemical Communications2016, 52, 1451-1454.

View more Publications