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Dr. P. Ravi Selvaganapathy

Professor and Canada Research Chair in Biomicrofluidics

Department of Mechanical Engineering

Professor

McMaster School of Biomedical Engineering

Expertise:
Micro/Nanofabrication; Bioprinting; Biomedical Microdevices; Microelectromechanical Systems; Microfluidics; Medical and Environmental Sensors; Smart Textiles; Artificial Organs
Research Clusters:

Overview

Our expertise is in the microfabrication technology and in microfluidics. We are interested in developing fabrication and integration processes for new materials in microdevices. We are also interested in developing components such as micropumps, microvalves, micromixers and microfluidic nozzles that could be used in a number of applications. We apply this expertise to build innovative micro and nanoscale devices for use in environmental and medical diagnostics, drug discovery, drug delivery and as artificial organs. 

Specific Research Interests

 Environmental sensors and continuous monitoring systems

Medical diagnostic sensors and lab on chip devices

Microfluidic devices for drug discovery and high throughput screening 

Microfabricated needles for injection and drug delivery

Artificial Organs

Bioprinting

3D printing of silicones

Additive manufacturing methods for sensors and microfluidic devices

Education

B.S, Central Electrochemical Research Institute,  India,1998;

M.S, Ph.D, University of Michigan, U.S.A. 2002;

Post Doctoral Research, Sandia National Laboratories, U.S.A. 2004.

Biography

Dr. P. Ravi Selvaganapathy is a Professor of Mechanical and Biomedical Engineering at McMaster University, Canada. He is also the Canada Research Chair in Biomicrofluidics. He completed his B.S. in chemical and electrochemical engineering (1998) from Central Electrochemical Research Institute, India. He then obtained his M.S and Ph.D in electrical engineering (2002) from University of Michigan, Ann Arbor. He was a postdoctoral fellow at Sandia National Laboratories from 2003-2004 and joined McMaster University in 2005. His research interests are in the development of microfluidic devices for drug discovery, drug delivery, diagnostics and artificial organs. He has more than 20 years of extensive experience in the micro/nano fabrication and microfluidics in the areas of medical and environmental diagnostics, drug delivery and drug discovery which has resulted in ~75 publications, in the top journals in the field. In addition he has published more than 50 refereed conference papers and has presented 25 invited talks at conferences, universities and other forums. His research has won a number of best paper awards and has been selected as cover articles for journals. He has written 6 invited book chapters and been issued 6 US patents related to MEMS/microfluidic devices. Two of his technologies has been licensed for commercialization and he has consulted with a number of leading companies in the field. Some of his research has been featured in scientific media such as Popular Mechanics as wells as in mainstream media such as CBC News, and in newspapers across Canada. He also received the Early Researchers Award from the ministry of research and innovation in 2010 and has been named as a Rising Star in Global Health by Grand Challenges Canada in 2012.

Publications

Recent

  1. R. Ghaemi, P. Arefi, A. Stosic, M. Acker, Q. Raza, J.R. Jacobs, P.R. Selvaganapathy, A microfluidic microinjector for toxicological and developmental studies in Drosophila embryos, Lab on a Chip, (2017) (accepted)
  2. E. Hoque, H.H. Hsu, A. Aryasomayajula, P.R. Selvaganapathy, P. Kruse, Pencil-drawn chemiresistive sensor for free chlorine in water, IEEE Sensor Lett., 1, 4500504, (2017)
  3. A. Mohtasebi, A. Broomfield, T. Chowdhury, P.R. Selvaganapathy, P. Kruse, Reagent-free quantification of aqueous free chlorine via electrical read-out of colorimetrically functionalized pencil lines, ACS Appl. Mat. Int., 9, 20748-20761, (2017)
  4. J. Liu, J. Mahony, P. Ravi Selvaganapathy, Low-cost and versatile integration of microwire electrodes and optical waveguides into silicone elastomeric devices using modified xurographic methods, npj Microsystems and Nanoengineering, 3, 17040, (2017)
  5. R. Ghaemi, P. Rezai, F.R. Nejad, P.R. Selvaganapathy, Characterization of microfluidic clamps for immobilizing and imaging of Drosophila Melanogaster larva’s central nervous system, Biomicrofluidics, 11, 034113, (2017)
  6. K. Russel, P.R. Selvaganapathy, C.Y. Ching, Electrical discharge characteristics of a dielectric liquid under external flow in a microchannel with planar electrode configuration, J. Electrostatics, 87, 212-216, (2017)
  7. S. Islam, A. Aryasomayajula, P. Ravi Selvaganapathy, A review on macroscale and microscale cell lysis methods, Micromachines, 8, 83, (2017) (invited)
  8. S. Islam, K. Kuryllo, A. Shahid, Y. Li, M.J. Deen, Ravi Selvaganapathy, Electrophoretic concentration and electrical lysis of bacteria in a microfluidic device using a nanoporous membrane, Micromachines, 8,45, (2017) (invited)
  9. H. Hsu, M.J. Deen, P.R. Selvaganapathy, Complete solid state dissolved oxygen sensor using hemin electrocatalyst and palladium-reusable reference electrode, IEEE Sensors, (2017) (accepted).
  10. H. Hsu, A. Aryasomayajula, P.R. Selvaganapathy, A review of sensing systems and their need for environmental water monitoring, Critical Reviews in Biomedical Engineering, 44, 357-382, (2016).
  11. S. Ayyash, W.I. Wu, P. R. Selvaganapathy, Fast and inexpensive detection of bacterial viability and drug effectiveness through metabolic monitoring, Sensors, 16, 1879, (2016) (invited - special issue on Biomicrofluidics)
  12. K. Russel, S.M. Hasnain, P. R. Selvaganapathy, C. Y. Ching, Effect of doping Ferrocene in the working fluid of electrohydrodynamic (EHD) micropumps, Microfluidics and Nanofluidics, 20, 112 (2016)
  13. R. Ghaemi, P.R. Selvaganapathy, Microfluidic Devices for Automation of Assays on Drosophila Melanogaster for Applications in Drug Discovery and Biological Studies, Current Pharmaceutical Biotechnology, 17, 822-836, (2016) (invited)
  14. K. Russel, P. R. Selvaganapathy, C. Y. Ching, Ion Drag Electrohydrodynamic (EHD) Micro-Pumps under a Pulsed Voltage, Journal of Electrostatics, 82, 48-54, (2016)
  15. Y. Qin, H.-J. Kwon, A. Subrahmanyam , M.M.R. Howlader, P. Ravi Selvaganapathy, A. Adronov, M. Jamal Deen, Inkjet-printed bifunctional carbon nanotubes for pH sensing, Material letters, 176, 68-70, (2016)
  16. D. Liu, B.Gupta, P. R. Selvaganapathy, An Automated Microfluidic System for Screening Caenorhabditis elegans Behaviors using Electrotaxis, Biomicrofluidics, 10, 014117 (2016)
  17. R. Attala, C. Ling, P.R. Selvaganapathy, Fabrication and characterization of gels with integrated channels using 3D printing with microfluidic nozzle for tissue engineering applications, Biomedical Microdevices, 18, 1-12, (2016).
  18. M. Doreswamy, C. Fusch, P. R. Selvaganapathy, H. Matharoo, S. Shivananda, A comparison of the prototype neonatal offset-blade laryngoscope (NOBL) versus the Miller laryngoscope in a manikin, Anaesthesia, 71, 320-325, (2015).
  19. Y. Qin, A.U. Alam, S. Pan, M.M.R. Howlader, R. Ghosh, P.R. Selvaganapathy, Y. Wu, M.J. Deen, Low-Temperature Solution Processing of Palladium/Palladium Oxide Films and Their pH Sensing Performance, Talanta, 146, 517-524, (2015).
  20. J. Yang, P.R. Selvaganapathy, T.J. Gould, D.J. Dwivedi, D. Liu, A.E. Fox-Robichaud, P.C. Liaw, A Microfluidic Device for Rapid Quantification of Cell-free DNA in Patients with Severe Sepsis, Lab on a Chip, 15, 3925 – 33, (2015).
  21. C. Feng, O. Marinov, M.J. Deen, P.R. Selvaganapathy, Y. Wu, Sensitivity of the threshold voltage of organic thin-film transistors to light and water, J. Appl. Phys. 117, 185501 (2015)
  22. T. Guo, M.J. Deen, C.Q. Xu, Q. Fang, P.R. Selvaganapathy, H. Zhang, Observation of Ultra-slow Stress Release in Silicon Nitride Films on CaF2, Journal of Vacuum science and Technology A, 33, 041515, (2015).
  23. M. Leung, L.R. Berry, H.M. Atkinson, R.M. Cornelius, D. Sandejas, N. Rochow, P.R. Selvaganapathy, C. Fusch, A.K.Chan, J.L. Brash, Surface modification of poly(dimethylsiloxane) with a covalent antithrombin–heparin complex for the prevention of thrombosis: use of polydopamine as bonding agent, J. Mater. Chem. B, 3, 6032 - 36, (2015)
  24. K. Russel, P. R. Selvaganapathy, C. Y. Ching, Electrohydrodynamic Injection Micropump with Single Walled Carbon Nanotube Electrodes, Journal of Microelectromechanical Systems, 24, 1557-1564, (2015).
  25. J .Piazza, C.Zhu, P.R. Selvaganapathy, T. Hoare, B. Jain, F. Hossain, R.K. Mishra, A Novel Intranasal Spray Device for the Administration of Nanoparticles to Rodents, Journal of Medical Devices, 9, 041001, (2015)
  26. G. Layton, W. I. Wu, P.R. Selvaganapathy, S. Friedman, A. Kishen. Fluid dynamics and biofilm removal generated by syringe-delivered and two ultrasonic assisted irrigation methods: A novel experimental approach. J. of Endodontics, 41, 884-889 (2015) (Best Paper Award in Basic Science and Technology category)
  27. H. Hsu, E. Hoque, P. Kruse, P. R. Selvaganapathy, A Carbon Nanotube Based Resettable Sensor for Measuring Free Chlorine in Drinking Water, Appl. Phy. Lett., 106, 063102 (2015) 
  28. R. Ghaemi, P. Rezai, B. Iyengar, P.R. Selvaganapathy, Microfluidic devices for imaging neurological response of Drosophila Melanogaster Larva to Auditory Stimulus, Lab on Chip 15, 1116-1122, (2015)  (in top 30 downloaded papers in Lab on Chip journal in Jan 2015)
  29. T. Guo, Y. Wei, C.Q. Xu, B. R. Watts, Z. Zhang, Q. Fang , H. Zhang, P. R. Selvaganapathy, M. J. Deen, Counting of E. Coli by a Micro-flow Cytometer Based on a Photonic-Microfluidic Integrated Device, Electrophoresis, 36, 298-304, (2015) 
  30. Z. Li, M.J. Deen , S. Kumar, P. R. Selvaganapathy, Raman Spectroscopy for In-Line Water Quality Monitoring – Instrumentation and Potential, Sensors, 14, 17275-17303, (2014) 
  31. K. Russel, P. R. Selvaganapathy, C. Y. Ching, Effect of electrode surface topology on charge injection characteristics in dielectric liquids: An experimental study, Journal of Electrostatics, 72, 487-492, (2014).
  32. H. Hsu, P.R. Selvaganapathy, J. Brash, Q. Fang, C.Q. Xu, J. Deen, H. Chen, Development of a Low-Cost Hemin-based Dissolved Oxygen Sensor with Anti-Biofouling Coating for Water Monitoring, IEEE Sensors Journal, 14, 3400-3407, (2014) (invited)
  33. Y. Qin, Matiar M.R. Howlader, M.J. Deen, Y.M. Haddara, P.R. Selvaganapathy, Polymer Integration for Packaging of Implantable Sensors, Sensors and Actuators-B, Chem. 202, 758-778, (2014).
  34. H. Hsu, P.R. Selvaganapathy, L. Soleymani, Bottom-up top-down fabrication of structurally- and functionally- tunable hierarchical palladium materials, Journal of Electrochemical Society, 161, D3078-3086, (2014) 
  35. J. Piazza, T. Hoare, L. Molinaro, K. Terpstra, J. Bhandari, P.R. Selvaganapathy, B. Gupta, R.K. Mishra, Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)-block-poly(d,l)-lactic-co-glycolic acid (PEG-PLGA) nanoparticles for the treatment of schizophrenia, Eur. J. Pharm. Biopharm., 87, 30-39, (2014)
  36. N Rochow, Manan, W.-I Wu, G. Fusch, S. Monkman, J.Leung, E. Chan, D. Nagpal, D. Predescu, J. Brash, P. Ravi Selvaganpathy,C. Fusch, An integrated array of microfluidic oxygenators as a neonatal lung assist device: invitro characterization and invivo demonstration, Artificial Organs, 38, 856-866, (2014)

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Achievements

  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2016)
  • Best Paper Award - Basic Science and Technology- Journal of Endodontics (2016)
  • NSERC Discovery Accelerator Supplement Award (2015)
  • Best Paper Award - Chemical Sensors - IEEE Sensors Conference (2014)
  • McMaster Synergy Award for Interdisciplinary Collaboration (2014)
  • Dean’s Honor Roll for Teaching (2014)
  • Rising Star in Global Health Award, Grand Challenges Canada, (2012)
  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2011)
  • Early Researchers Award, Ontario Ministry of Research and Innovation, (2010)