Skip to main content

Dr. David Latulippe

Assistant Professor

Department of Chemical Engineering

Expertise:
separation processes for water/wastewater treatment, biopartitioning and purification, microscale processing for high-throughput studies,unit operation modeling and optimization
Areas of Specialization:
Research Clusters:

Overview

 

Research Interests

The overarching theme of my research group is the development and optimization of novel separation processes.  Toward this end, we typically focus on microscale processes (MSP) - the study of conventional processes (e.g. chromatography, membrane filtration, adsorption) but in miniaturized formats such as micro-columns, micro-well plates, and microfluidic devices. The advantages of this approach are considerable - it is extremely cost-effective since it requires minimal amounts of material and it is very efficient since it uses a parallel architecture approach. Our research uses a unique combination of experimental work, statistical analysis, and advanced tools for sample characterization and process modelling.

Microscale processing in environmental engineering:

We are developing novel separation processes for a variety of 'tough-to-treat' applications including tailings (i.e. suspensions of clay particles) from mining operations, biosolids from municipal WW treatment, and vegetable 'wash-water' from agricultural processing.  Our work includes both physical, chemical and biological-based processes including the development of the first ever high-throughput microscale stirred cell filtration device for flat sheet membranes, the first ever high-throughput microscale filtration device for hollow fiber membranes, a lab-scale anaerobic digester featuring recuperative thickening technology.  Our lab is home to the Micro-scale Separations and Analysis Suite (MSAS), a collection of specialized equipment that is essential for the execution and analysis of micro-scale experiments, that was supported by the Canada Foundation for Innovation (CFI), Ontario Research Fund (ORF), and NSERC Research Tools and Instrumentation (RTI) programs.

Downstream purification of oncolytic viruses:

We are working to solve the considerable challenges associated with the downstream purification of oncolytic viruses (OVs), an innovative anti-cancer therapeutic that has attracted considerable attention. The establishment of a cost-effective OV manufacturing process is critically dependent on the development of new technologies for downstream processing - the finished product must be of a sufficiently high purity and immunogenic activity (to fulfill regulatory demands) that is ready for clinical trials and full-scale commercialization.  This work is being done in collaboration with scientists at the Ottawa Hospital Research Institute and University of Toronto through the Alliance for Biotherapeutics Manufacturing Innovation (ABMI).

 

Project Title


Industrial Partner

Supporting Funding Agency

Industrial wastewater treatment within the "design space" scientific framework

 

 

OCE

 

 Development of next-generation engineered textiles for sludge and tailings dewatering applications

CGT-logo

 

OCE

Quantitative evaluation of biocide contamination in industrial wastewater using PeCOD technology

NSERC

 

Positions Available:

  • Undergraduate Students – Undergraduate research is an outstanding learning experience both for students seeking careers in industry and those interested in graduate school. NSERC has funding available specifically for undergraduate students – for more details see http://www.nserc-crsng.gc.ca/students-etudiants/ug-pc/usra-brpc_eng.asp. Senior-year students in any of the chemical engineering programs have the opportunity to join our lab as part of the ChE 4Y4 independent project course. Interested students should email
    Dr. David Latulippe (preferably with an attached resume).
  • Graduate students – There are positions available in our group for outstanding, highly-motivated and enthusiastic students. Those interested in joining the group should follow the application instructions on thedepartment website Inquiries about our research by prospective graduate students are strongly encouraged – please email Dr. David Latulippe. However, administrative questions relating to the admissions process should be directed to the graduate secretary

Education

  • B. Eng. Chemical Engineering, McMaster University (2000)
  • M.A.Sc. Chemical Engineering, McMaster University (2005)
  • Ph.D. Chemical Engineering, Pennsylvania State University (2010)
  • Post-Doctoral Associate Applied & Engineering Physics, Cornell University (2010-2012)

Biography

I joined McMaster in July 2012 following post-doctoral work (in the School of Applied and Engineering Physics at Cornell University) on the development of microscale technologies for biological systems.  Prior to that I completed my Ph.D. (in the Department of Chemical Engineering at The Pennsylvania State University) on the development of membrane filtration processes for DNA purification.  Between my undergraduate and masters degrees I worked in the membrane manufacturing division at ZENON Environmental (now GE Water) on the design and development of hollow-fiber membrane systems for water treatment.  In 2014 I was awarded the Young Membrane Scientist Award from the North American Membrane Society (NAMS).  I am currently leading a number of dynamic collaborations with various industrial (e.g. Ceapro, Aevitas) and academic partners.

Publications

Selected

A.S. Kazemi, L. Boivin, S.M. Yoo, R. Ghosh, D.R. Latulippe

Elucidation of filtration performance of hollow-fiber membranes via a high-throughput screening platform

Journal of Membrane Science, vol. 533, pp. 241–249,

A.S. Kazemi, K. Kawka, D.R. Latulippe

Optimization of bio-molecule separation by combining microscale filtration and design-of-experiment methods

Biotechnology and Bioengineering, vol. 113, no. 10, pp. 2131–2139

Cobbledick, N. Aubry, V. Zhang, S. Rollings-Scattergood, D.R. Latulippe,

Lab-scale demonstration of recuperative thickening technology for enhanced biogas production and dewaterability in anaerobic digestion processes

Water Research 95 (2016) 39-47

R.J. LaRue, J. Cobbledick, N. Aubry, E.D. Cranston, D.R. Latulippe

The microscale flocculation test (MFT) - a high-throughput technique for optimizing separation performance

Chemical Engineering Research and Design 105 (2016) 85–93

S. Shoaebargh, I. Gough, M. Fe Medina, A. Smith, J. van der Heijden, B.D. Lichty, J.C. Bell, D.R. Latulippe

Sterile filtration of oncolytic viruses: an analysis of effects of membrane morphology on fouling and product recovery

Journal of Membrane Science 548 (2018) 239-246.

View more Publications