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Dr. Zeinab Hosseinidoust

Assistant Professor

Department of Chemical Engineering

Expertise:
Bacteriophage Biotechnology, Bacterial Biofilms, Phage Antimicrobials, Targeted Antimicrobial Delivery, Biohybrid Systems
Areas of Specialization:
Research Clusters:

Overview

We address the global crisis of antimicrobial resistant superbugs by using bacteriophages, good viruses that are bacteria's natural predators. These natural antimicrobials can be designed to act as tiny soldiers that only kill the bad bacteria and leave our good bacteria (the ones we need for our health and well-being) intact. We also pack bacteriophages into solid form to design antimicrobial biomaterials, gels and coatings. In addition, because bacteriophages are so good at targeting their prey (bacteria) in nature, we use them to design novel methods of detecting and diagnosing infectious diseases.  Our research spans across multiple disciplines and integrates engineering with molecular biology, materials science, and chemistry. To learn more, follow us on Twitter and Instagram. You can also visit the Resources page on my lab website to learn more about bacteriophages.

Research Platforms

Platform A: Phage Antimicrobials

We use bacteriophages for their inherent property, as bacterial killers. We use bacteriophages to fight common infections, biofilm infections, and specifically those that are antibiotic resistant. 

Platform B: Phage Biomaterials

in their simplest form, bacteriophages are bionanoparticles than can propagate themselves and self assemble. These properties make bacteriophages more powerful than synthetic nanoparticles.

Platform C: Phage Diagnostics

Bacteriophages are very effective at finding and specifically targeting their host bacteria in nature. We use this property to design better diagnostic tools.

Education

  • PDF, Max Planck Institute for Intelligent systems, Germany, 2016
  • Ph.D., McGill University, Montreal, Canada, 2013
  • B.Sc., Sharif University of Technology, Tehran, Iran, 2003

Did you know…

Phages are viruses that infect bacteria. They were discovered 100 years ago and have been used as natural antibacterials ever since. With the rising crisis of antibiotic resistance, phages could be our hope for a post-antibiotic era. 
Our lab works on developing engineering solutions to global health problems using phages. If you want to learn more about phages, visit our lab website: https://www.biohybridslab.com/resources
 
For Prospective Students: We welcome applications from highly motivated students that share our passion for science and curiosity about phages and their applications. If you want to join my lab as a graduate student or a postdoc, please contact me directly with your latest transcripts and an up-to-date CV. Every year our lab hosts numerous NSERC-USRA and undergraduate thesis students. If you are an undergraduate student looking to do research for credit or to satisfy your own curiosity, do not hesitate to contact me with your latest transcripts and CV. 
 
For postdocs: Currently, we welcome applications from postdoctoral applicants that hold a major Canadian or international fellowship.
 
For potential Academic or Industrial Collaborators: Please see our lab website to learn more about our research expertise (https://www.biohybridslab.com/publications) and also about the equipment and unique facilities we can offer as part of a collaborative project: https://www.biohybridslab.com/facilities

Biography

I am a chemical engineer, fascinated by microbiology. For the past 10 years, I have been working on employing the intelligence of biological systems (specifically bacteriophages and bacteria) to tackle the outstanding challenges related to human health. I joined the Chemical Engineering Department at McMaster in July 2016. I am also an associate member at the Micheal DeGroote Institute for Infectious Disease ResearchThe Farncombe Institute and the School of Biomedical Engineering.

Publications

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