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Dr. P. Ravi Selvaganapathy

Co-Director (Engineering)

McMaster School of Biomedical Engineering

Professor

McMaster School of Biomedical Engineering

Distinguished Engineering Professor, Canada Research Chair in Biomicrofluidics (laureate)

Department of Mechanical Engineering

Expertise:
Micro/Nanofabrication; Bioprinting; Biomedical Microdevices; Microelectromechanical Systems; Microfluidics; Medical and Environmental Sensors; Smart Textiles; Biomaterials; Artificial Organs
Areas of Specialization:
Research Clusters:
Email:
Office:
ETB-406 (Mail to JHE-310)
Phone:
+1 905.525.9140 x 27435
Lab:
JHE A110

Overview

Our expertise is in the microfabrication technology and in microfluidics. We are interested in developing fabrication and integration processes for new materials in microdevices. We are also interested in developing components such as micropumps, microvalves, micromixers and microfluidic nozzles that could be used in a number of applications. We apply this expertise to build innovative micro and nanoscale devices for use in environmental and medical diagnostics, drug discovery, drug delivery and as artificial organs. 

Specific Research Interests

 Environmental sensors and continuous monitoring systems

Medical diagnostic sensors and lab on chip devices

Microfluidic devices for drug discovery and high throughput screening 

Artificial Organs

Bioprinting and Cultivated Meat

3D printing of silicones and reactive polymers

Additive manufacturing methods for sensors and microfluidic devices

Smart textiles and protective wearables

Education

B.S, Central Electrochemical Research Institute,  India,1998;

M.S, Ph.D, University of Michigan, U.S.A. 2002;

Post Doctoral Research, Sandia National Laboratories, U.S.A. 2004.

Biography

Dr. P. Ravi Selvaganapathy is a Professor of Mechanical and Biomedical Engineering at McMaster University, Canada. He is also a Distiguished Engineering Professor and was the Canada Research Chair laureate in Biomicrofluidics. He completed his B.S. in chemical and electrochemical engineering (1998) from Central Electrochemical Research Institute, India. He then obtained his M.S and Ph.D in electrical engineering (2002) from University of Michigan, Ann Arbor. He was a postdoctoral fellow at Sandia National Laboratories from 2003-2004 and joined McMaster University in 2005. His research interests are in the development of microfluidic devices for drug discovery, drug delivery, diagnostics and artificial organs. He has more than 20 years of extensive experience in the micro/nano fabrication and microfluidics in the areas of medical and environmental diagnostics, drug delivery and drug discovery which has resulted in ~140 publications, in the top journals in the field. In addition he has published more than 70 refereed conference papers and has presented 35 invited talks at conferences, universities and other forums. His research has won a number of best paper awards and has been selected as cover articles for journals. He has written 6 invited book chapters and been issued 9 US patents related to MEMS/microfluidic devices. Many of his technologies has been licensed for commercialization and he has consulted with a number of leading companies in the field and he is a co-founder of CaroMeats which aims to commercialize cultivated meat. Some of his research has been featured in scientific media such as Popular Mechanics as wells as in mainstream media such as CBC News, and in newspapers across Canada. He also received the Early Researchers Award from the ministry of research and innovation in 2010 and has been named as a Rising Star in Global Health by Grand Challenges Canada in 2012.

Publications

Recent

  1. Sayed, P.R. Selvaganapathy, High resolution fabrication of nano patterns by multi-step iterative miniaturization of hot embossed pre-stressed polymer films and constrained shrinking, Microsystems and Nanoengineering, (2021) (accepted)
  2. Zhou, E. Doman, K. Schirrmann, Q. Chen, E. Seed, E.D. Johnstone, P.R. Selvaganapathy, A. Juel, M.O. Bernabeu, T. Kruger, I.L. Chernyavsky, Micro-haemodynamics at the maternal–fetal interface: experimental, theoretical and clinical perspectives, Current Opinion in Biomedical Engineering, (2021) (accepted)
  3. Dabaghi, N. Tiessen, Q. Cao, A. Chandiramohan, N. Saraei, Y. Kim, T. Gupta, P.R. Selvaganapathy, J.A. Hirota, Adhesive-based fabrication technique for culture of lung airway epithelial cells with applications in cell patterning and microfluidics,  ACS Biomater. Sci. Eng. (2021) (accepted)
  4. Saha, V. Patel, P.R. Selvaganapathy, P. Kruse, Facile fabrication of conductive MoS2 thin films by sonication in hot water and evaluation of their electrocatalytic performance in the hydrogen evolution reaction, Nanoscale Advances, (2021) (accepted)
  5. Angizi, E. Yu, J. Dalmieda, D. Saha, P.R. Selvaganapathy, P. Kruse, Defect engineering of graphene to modulate the pH response of graphene devices, Langmuir, (2021) (accepted)
  6. Damodara, Y. Zhu, P.R. Selvaganapathy, Patterned threads as solid-state reagent storage and delivery medium for automated periodic colorimetric monitoring of the environment, Microfluidics Nanofluidics, (2021) (accepted)
  7. Patel, P. R. Selvaganapathy, Enhancing the sensitivity of cobalt based solid-state phosphate sensor using electrical pretreatment, Sens. & Act. B: Chem., (2021) (accepted)
  8. Kumbhare, S. Hassan, D. Diep, F.C.K. Duarte, J. Hung, S. Damodara, D.W.D West, P. R. Selvaganapathy, Potential role of blood biomarkers in fibromyalgia patients,Pain, (2021) (accepted)
  9. Sayed, P.R. Selvaganapathy, Constrained shrinking of nanoimprinted pre-stressed polymer films to achieve programmable, high-resolution, miniaturized nanopatterns, Nanotechnology, 32, 505301, (2021)
  10. Dalmieda, A.L. Zubiarrain, D. Saha, P.R. Selvaganapathy, P. Kruse, Impact of surface adsorption on metal-ligand binding of phenanthrolines, J. Phys. Chem., (2021) (accepted)
  11. Wu, M. Tauhiduzzaman, P.R. Selvaganapathy, Anisotropic wetting surfaces machined by diamond tool with tips microstructured by focused ion beam, Materials & Design, 210, 110014, (2021)
  12. Sliwiak, R. Bui, M.A. Brook, P.R. Selvaganapathy, 3D printing of highly reactive silicones using inkjet type droplet ejection and free space droplet merging and reaction, Additive Manufacturing, 46, 102099, (2021)
  13. Fusch, N. Rochow, P.R. Selvaganapathy, Reply to the “Comment on ‘A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress’”, Advanced Science, 8, 2100831, (2021).
  14. Dabaghi, S. Shahriari, N. Saraei, K. Da, A. Chandiramohan, P.R. Selvaganapathy, J. Hirota, Surface Modification of PDMS-based Microfluidic devices with collagen using polydopamine as a spacer to enhance primary human bronchial epithelial cells adhesion, Micromachines, 12, 132, (2021)
  15. K.B. Taylor, M.H. Minhas, J. Tong, P.R. Selvaganapathy, R.K. Mishra, B.P. Gupta, Mitochondrial and ER stress signaling modulate electrotaxis behaviour in C. elegans, Scientific Reports, 11, 3115, (2021)
  16. Shamsabadi, P.R. Selvaganapathy, Engineering murine adipocytes and skeletal muscle cells in meat-like constructs using self-assembled layer-by-layer biofabrication: A platform for development of cultivated meat, Cells Tissues Organs, (2021) (accepted) (invited for special issue)
  17. Patel, P. Kruse, P.R. Selvaganapathy, Solid state sensors for hydrogen peroxide detection, Biosensors, 11, 9, (2021)
  18. Damodara, D.J. Dwivedi, P.C. Liaw, A.E. Fox-Robichaud, P. Ravi Selvaganapathy, Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics, Sens. & Act. B: Chem., 330, 129265, (2021)
  19. Dalmieda, A. Zubiarrain-Laserna, D. Ganepola, P.R. Selvaganapathy, P. Kruse, Chemiresistive detection of silver ions in aqueous media, Sens. & Act. B: Chem., 328, 129023, (2021)
  20. Sayed, P.R. Selvaganapathy, Multi-step proportional miniaturization to nanoscale dimensions using pre-stressed polymer films, Nanoscale Advances, 2, 5461 - 5467 (2020)
  21. Saha, P.R. Selvaganapathy, P. Kruse, Peroxide-Induced Tuning of the Conductivity of Nanometer-Thick MoS2 Films for Solid State Sensors, ACS Applied Nano Materials, 3, 10864-10877, (2020)
  22. Shamsabadi, P.R. Selvaganapathy, π-SACS: pH induced self-assembled cell sheets without the need for modified surfaces, ACS Biomaterials Science and Engineering, 6, 5346-5356, (2020)
  23. Dabaghi, N. Rochow, N. Saraei, G. Fusch, S. Monkman, K. Da, A. Shamsabadi, J.L. Brash, D. Predescu, K. Delaney, C. Fusch, P. R. Selvaganapathy, A pumpless microfluidic neonatal lung assist device for support of preterm neonates in respiratory distress, Advanced Science, 7, 2001860 (2020)
  24. A. Shamsabadi, P.R. Selvaganapathy, Tissue in a Tube: 3D In vitro tissue constructs with integrated multimodal environmental stimulation, Materials Today Bio, 7, 100070, (2020)
  25. Ahmed, Y.-S. Guan, I. Hassan, C. Ling, Z. Li, I. Mosa, G. Phadke, P. R. Selvaganapathy, S. Chang, S. Ren, Multifunctional smart electronic skin fabricated from two-dimensional like polymer film, Nano Energy, 75, 105044, (2020)
  26. Elango, P. R. Selvaganapathy, G. Lazzari, B. Bao, W. Wenhui, Biomimetic collagen-sodium alginate-titanium oxide (TiO2) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration, International Journal of Biological Macromolecules, 163, 9-18, (2020)
  27. Dabaghi, N. Rochow, N. Saraei, R.K. Mahendran, G. Fusch, A.K. Chan, J.L. Brash, C. Fusch, P. R. Selvaganapathy, Miniaturization of artificial lungs towards portability, Advanced Materials Technologies, 5, 2000136, (2020) (highlighted by an invited article in Advanced Science News)
  28. A. Ionescu, D.J. Harris, P.R. Selvaganapathy, A. Kishen, Electrokinetic transport and distribution of antibacterial nanoparticles for endodontic disinfection, Int. Endodontic Journal, 53, 1120-1130 (2020)
  29. K. Wong, E.W. Li, M. Adam, P.R. Selvaganapathy, S. Raha, Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels, Molecular Human Reproduction, 26, 353-365, (2020)
  30. Shamsabadi, P.R. Selvaganapathy, A 3D self assembled in vitro model to simulate direct and indirect interactions between adipocytes and skeletal muscle cells, Advanced Biosystems, 4, e2000034, (2020)
  31. Xiao, R. Wu, J.J Huang, P.R. Selvaganapathy, Anode surface modification regulates biofilm community population and the performance of micro-MFC based biochemical oxygen demand sensor, Chem. Engg. Sci., 221, 115691, (2020)
  32. Ghaemi, J. Tong, B. Gupta, P. R. Selvaganapathy, Microfluidic device for microinjection of Caenorhabditis elegans, Micromachines, 11, 295, (2020) (invited) (10th Anniversary special issue)
  33. Mohammadzadeh, A. Fox-Robichaud, P. R. Selvaganapathy, Electroplating of multiple materials in parallel using patterned gels with applications in electrochemical sensing, Sensors, 20, 886, (2020) (invited)
  34. Xiao, P.R. Selvaganapathy, R. Wu, J.J Huang, Influence of wastewater microbial community on the performance of miniaturized microbial fuel cell biosensor, Bioresource Technology, 302, 122777, (2020)
  35. Dabaghi, N. Saraei, G. Fusch, N. Rochow, J.L. Brash, C. Fusch, P. R. Selvaganapathy, Microfluidic blood oxygenators with integrated hollow chambers for enhanced air exchange from all four sides, J. Membrane Sci., 596, 117741, (2020)
  36. Xiao, R. Wu, J.J. Huang, P.R. Selvaganapathy, Development of a xurographically fabricated miniaturized low-cost, high-performance microbial fuel cell and its application for sensing biological oxygen demand, Sensors & Actuators B: Chem., 304, 127432, (2020)
  37. Lee, A. Shamsabadi, P.R. Selvaganapathy, K. Grandfield, A bioprinted in vitro model for osteoblast to osteocyte transformation by changing mechanical properties of the ECM, Advanced Biosystems, 3, 1900126, (2019) (featured on the cover)
  38. Mahoney, H.H. Hsu, F. Du, B. Xiong, P.R. Selvaganapathy, Q. Fang, Optofluidic dissolved Oxygen sensing with sensitivity enhancement through multiple reflections, IEEE Sensors, 19, 10452-10460, (2019)
  39. Dabaghi, N. Saraei, G. Fusch, N. Rochow, J. Brash, C. Fusch, P. R. Selvaganapathy, An ultra-thin, all PDMS-based microfluidic lung assist device with high oxygenation capacity, Biomicrofluidics, 13, 034116 (2019)
  40. Shahin-Shamsabadi, P. Ravi Selvaganapathy, A rapid fabrication technique for self-assembled collagen-based multicellular heterogeneous 3D tissue constructs, Acta Biomaterialia, 92, 172-183, (2019)
  41. Cevik, M. Acker, R. Ghaemi, P. Arefi, J. Zhang, P.R. Selvaganapathy, I. Dworkin, R. Jacobs, Chloroform and Desflurane immobilization with recovery of viable Drosophila larvae for confocal imaging, J. Insect Physiology, 117, 103900, (2019)
  42. Firouzi, C.Y. Ching, P.R. Selvaganapathy, Development of oxygen-plasma-surface-treated UHMWPE fabric coated with a mixture of  SiC/polyurethane for protection against puncture and needle  threats, Fibers, 7, 46, (2019) (invited)
  43. Mohammadzadeh, A. Fox-Robichaud, P.R. Selvaganapathy, Rapid and inexpensive method for fabrication and integration of electrodes in microfluidic devices, J. MEMS, 28, 597-605, (2019)
  44. Ahmed, I. Hassan, M. El-Kady, A. Radhi, C.K. Jeong, P.R. Selvaganapathy , S. Ren, Q. Wang, R.B. Kaner, Integrated Triboelectric Nanogenerators in the Era of Internet of Things: A review, Advanced Science, 6, 1802230, (2019)
  45. Guo, P. Koshy, F. Coelho, P.R. Selvaganapathy, Sink electrical discharge machining of hydrophobic surfaces, CIRP annals – Manufacturing Technology, 68, 185-188, (2019)
  46. Ahmed, I. Hassan, I.M. Mosa, E. Elsanadidy, G.S. Phadke, M.F. El-Kady, J.F. Rusling, P.R. Selvaganapathy, R.B. Kaner, All printable snow-based triboelectric nanogenerator, Nano Energy, 60, 17-25, (2019)
  47. Ahmed, M.F. El-Kady, I. Hassan, A. Negm, A.M. Pourrahimi, M. Muni, P.R. Selvaganapathy, R.B. Kaner, Fire-Retardant, Self-Extinguishing Triboelectric Nanogenerators, Nano Energy, 59, 336-345, (2019)
  48. M .Osborne, Aryasomayajula, A. Shakeri, P.R. Selvaganapathy, T. Didar, Suppression of Biofouling on a Permeable Membrane for Dissolved Oxygen Sensing using a Lubricant-Infused Coating, ACS Sensors, 4, 687-693, (2019)
  49. Shahin-Shamsabadi, P. Ravi Selvaganapathy, ExCeL: Combining Extrusion Printing on Cellulose Scaffolds with Lamination to Create In Vitro Biological Models, Biofabrication, 11, 035002, (2019)
  50. Attalla, E. Puersten, N. Jain, P.R. Selvaganapathy, 3D Bioprinting of Heterogeneous Bi- and Tri-layered Hollow Channels within Gel Scaffolds using Scalable Multi-Axial Microfluidic Extrusion Nozzle, Biofabrication, 11, 015012, (2019)
  51. Mohammadzadeh, A. Fox-Robichaud, P.R. Selvaganapathy, Rapid and inexpensive method for fabrication of multi-material multi-layer microfluidic devices, J. Micromech. Microeng., 29, 015013, (2019)
  52. Dabaghi, N. Saraei, G. Fusch, N. Rochow, J.L. Brash, C. Fusch, P.R. Selvaganapathy, An ultra-thin highly flexible microfluidic device for blood oxygenation, Lab on a Chip, 18, 3780 - 3789 (2018) (featured on the cover)
  53. Zheng, M. Zlatin, P. Ravi Selvaganapathy, M.A. Brook, Multiple modulus silicone elastomers using 3D extrusion printing of low viscosity inks, Additive Manufacturing, 24, 86-92, (2018)
  54. Madadkar, P.R. Selvaganapathy, R. Ghosh, Continuous flow microreactor for protein PEGylation, Biomicrofluidics, 12, 044114 (2018)
  55. Richman, S. Rashid, S. Prashar, R.K. Mishra, P.R. Selvaganapathy, B.P. Gupta, C. elegans MANF homolog is necessary for the protection of dopaminergic neurons and ER Unfolded Protein Response, Frontiers in Neuroscience, 12, 544, (2018)
  56. Firouzi, M.K. Russel, S.N. Rizvi, C.Y. Ching, P.R. Selvaganapathy, Development of flexible particle-laden elastomeric textiles with improved penetration resistance to hypodermic needles, Materials and Design, 156, 419-428, (2018)
  57. Wong, M.A. Green, S. Shawky, A. Aryasomyajula, T. Ewart, P. R Selvaganapathy, S. Raha, Extracellular matrix (ECM) surface regulates self-assembly of three-dimensional placental trophoblast spheroids, PLOS ONE, 13, e0199632,(2018)
  58. Dabaghi, G. Fusch, N. Saraei, N. Rochow, J. Brash, C. Fusch, P. R. Selvaganapathy, An artificial placenta type microfluidic blood oxygenator with double-sided gas transfer microchannels and its integration as a neonatal lung assist device, Biomicrofluidics, 12, 044101,(2018) (chosen as the Editor’s Pick)
  59. Umatheva, P. Madadkar, P.R. Selvaganapathy, R. Ghosh, Computational fluid dynamics (CFD) simulation of laterally-fed membrane chromatography, Chemical Engineering Research and Design, 137, 412-420, (2018)
  60. Ghaemi, M. Dabaghi, R. Attalla, A. Shahid, H.H. Hsu, P. R. Selvaganapathy, Use of flame activation of surfaces to bond PDMS to variety of substrates for fabrication of multimaterial microchannels, J. Micromech. Microeng. 28, 087001,(2018)
  61. Peng, N. Rochow, J. Jansen, D. Predescu, B. DeFrance, S.-Y. Lee, G. Fusch, P. Ravi Selvaganapathy, C. Fusch, Postnatal dilatation of umbilical cord vessels and its impact on wall integrity: Prerequisite for the artificial placenta, Artificial Organs, 41, 393-399, (2018)
  62. Matharoo, M. Dabaghi, N. Rochow, G. Fusch, N. Saraei, M. Tauhiduzzaman, S. Veldhuis, J. Brash, C. Fusch, and P.R. Selvaganapathy, Steel reinforced composite silicone membranes and its integration to microfluidic oxygenators for high performance gas exchange, Biomicrofluidics, 12, 014107, (2018).
  63. Deng, R. Attalla, L. Sadowski, M. Chen, M. Majcher, I. Urosev, D-C.Yin, P.R.  Selvaganapathy, C. Filipe, T. Hoare, Autonomously self-adhesive hydrogels as building blocks for additive manufacturing, Biomacromolecules, 19, 62-70, (2018) (featured on the cover) (Top 5 most downloaded research article, December 2018)
  64. Attalla, C.S. Ling, P.R. Selvaganapathy, Silicon carbide nanoparticles as an effective bioadhesive to bond collagen containing composite gel layers for tissue engineering applications, Advanced Healthcare Materials, 7, 1701385 (2018) (featured on the cover)
  65. H. Hsu, M.J. Deen, P.R. Selvaganapathy, Complete solid state dissolved oxygen sensor using hemin electrocatalyst and palladium-reusable reference electrode, IEEE Sensors, 18, 941-947, (2018).
  66. Kazemi-Zanjani,, M. Shayegannia, R. Prinja, A.O. Montazeri, A. Mohammadzadeh, K. Dixon, J. Zhu, P.R. Selvaganapathy, A. Zavodni, N. Matsuura, N.P. Kherani, Multiwavelength surface-enhanced raman spectroscopy using rainbow trapping in width-graded plasmonic gratings, Advanced Optical Materials, 6, 1701136,(2018)

View more Publications

Achievements

  • Editor’s Pick Award, Biomicrofluidics Journal (2018)
  • Dean’s Honor Roll in Graduate Supervision (2018)
  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2016)
  • Best Paper Award - Basic Science and Technology- Journal of Endodontics (2016)
  • NSERC Discovery Accelerator Supplement Award (2015)
  • Best Paper Award - Chemical Sensors - IEEE Sensors Conference (2014)
  • McMaster Synergy Award for Interdisciplinary Collaboration (2014)
  • Dean’s Honor Roll for Teaching (2014)
  • Rising Star in Global Health Award, Grand Challenges Canada, (2012)
  • Canada Research Chair Award (Tier II), Canada Research Chairs Program, (2011)
  • Early Researchers Award, Ontario Ministry of Research and Innovation, (2010)