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Matls 701/702: Kayla Baker, MASc Candidate

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MS Teams Code: ffuvgr3

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materials@mcmaster.ca

Advanced Inorganic-Organic Coatings for Biomedical Applications

Overview

A biomimetic approach is described for the fabrication of poly(ethyl methacrylate) (PEMA) coatings by a dip coating method. In this new approach, bile acids, such as cholic acid and lithocholic acid are used as solubilizing agents for PEMA. For the first time the fabrication of PEMA coatings from solutions in isopropanol and ethanol are demonstrated, avoiding the use of traditional toxic solvents. The analysis of deposition yield data and chemical structures of the bile acids provides an insight into the novel solubilization mechanism.

Building on the advanced properties of bile acids as natural dispersants, composite coatings containing various bioceramics, such as

hydroxyapatite, silica and titania in the PEMA matrix are obtained. Tetracycline and ibuprofen are used for the fabrication of drug-containing PEMA coatings. It is found that other functional molecules, such as heparin and nanocellulose can be incorporated into the PEMA matrix as well.

The approach developed in this investigation is promising for the fabrication of coatings for biomedical implants and devices using natural surfactants and avoiding the use of toxic solvents.