Department of Engineering Physics
School of Interdisciplinary Science
McMaster School of Biomedical Engineering
Biophotonics is a fast growing interdisciplinary field that concentrates on applying physical, chemical and engineering advances to biological and medical challenges.
Dr. Fang works on the development of optical spectroscopy and imaging systems for biomedical and environmental applications. His recent research projects include: multimodality optical biopsy techniques for real-time clinical diagnosis and guided therapy, optical endoscope designs for gastrointestinal cancer screening, fluorescence lifetime imaging microscopy (FLIM) technologies for high content screening; ultrafast laser micromachining for medical implants; miniaturized optical sensing and imaging technologies for environmental, point-of-care diagnosis, and aging research.
Dr. Fang is a member of:
He is also an Associate Member of:
Did you know…
Dr. Fang is the Canada Research Chair in Biophotonics and is cross-appointed with the School of Biomedical Engineering.
Bo Xiong, Tian-Qi Hong, Herb Schellhorn, Qiyin Fang, “Dual-Modality Imaging Microfluidic Cytometer for Onsite Detection of Phytoplankton,” Photonics 8, 435, 2021. doi:10.3390/photonics8100435 (Open Access)
Brenda Vrkljan, Marla K. Beauchamp, Paula Gardner, Qiyin Fang, Ayse Kuspinar, Paul D. McNicholas, K. Bruce Newbold, Julie Richardson, Darren Scott, Manaf Zargoush and Vincenza Gruppuso, “Re-engaging in Aging and Mobility Research in the COVID-19 Era: Early Lessons from Pivoting a Large-Scale, Interdisciplinary Study amidst a Pandemic,” Canadian Journal on Aging / La Revue Canadienne Du Vieillissement, 1-7, 2021, doi:10.1017/S0714980821000374 (Open Access)
Thomas Beyer, Dale L. Bailey, Udo J. Birk, Irene Buvat, Ciprian Catana, Zhen Cheng, Qiyin Fang, Federico Giove, Claudia Kuntner, Elmar Laistler, Francesco Moscato, Stephan G. Nekolla, Ivo Rausch, Itamar Ronen, Simo Saarakkala, Kris Thielemans, Wouter van Elmpt, and Ewald Moser, “Medical Physics and Imaging–A Timely Perspective,” Frontiers in Physics, 9: 206, 2021. doi.org/10.3389/fphy.2021.634693, (Open Access)
Ilko K. Ilev, David Nolte, Qiyin Fang, Giuliano Scarcelli, Yuji Matsuura, William Calhoun, Thomas Huser, “Editorial Introduction to JSTQE Special Issue on Biophotonics,” IEEE Journal of Selected Topics in Quantum Electronics, 27(4): 0200404, 2021, doi.org/10.1109/JSTQE.2021.3072401 (online)
Ramy Abdlaty, Lilian Doerwald-Munoz, Joseph Hayward, Thomas Farrell, Qiyin Fang, “Hyperspectral imaging assessment for radiotherapy induced skin-erythema: Pilot study,”, Photodiagnosis and Photodynamic Therapy, 33: 102195, 2021, doi.org/10.1016/j.pdpdt.2021.102195 (online)
Ramy Abdlaty, Joseph Hayward, Thomas Farrell, Qiyin Fang, “Skin erythema and pigmentation: a review of optical assessment techniques”, Photodiagnosis and Photodynamic Therapy, 33: 102127, 2021, (online)
Bo Xiong, Eric Mahoney, Joe F. Lo, Qiyin Fang, “A Frequency-domain optofluidic dissolved oxygen sensor with total internal reflection design for in situ monitoring”, IEEE Selected Topics in Quantum Electronics, 27(4):1-7 2021, doi.org/10.1109/JSTQE.2020.2997810 (Preprint PDF)
Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, “Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications,” IEEE Selected Topics in Quantum Electronics, 27(5):1-9, doi.org/10.1109/JSTQE.2020.2997834 (Preprint PDF)
Zhaojun Nie, Shu-Chi Allison Yeh, Michelle LePalud, Fares Badr, Frances Tse, David Armstrong, Louis W. C. Liu, M. Jamal Deen, and Qiyin Fang, “Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra,” Frontiers in Physiology, 11:339, 2020, doi.org/10.3389/fphys.2020.00339| (Open access)
Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, “Multiplexed confocal microscope with a refraction window scanner and a single-photon avalanche photodiode array detector,” Optics Letters 45(1): 69-72, 2020, doi.org/10.1364/OL.45.000069 (online)
Bo Xiong, Qiyin Fang, “Luminescence lifetime imaging using a cellphone camera with an electronic rolling shutter”, Optics Letters, 45(1): 81-84, 2020, doi.org/10.1364/OL.45.000081 (Online)
Eric Mahoney, Jessica Kun, Marek Smieja, Qiyin Fang, “Review—Point-of-Care Urinalysis with Emerging Sensing and Imaging Technologies,” Journal of Electrochemical Society, 167(3): 037518, 2020, doi.org/10.1149/2.0182003JES (Open Access)
Le V. N. Du, Manser Myla, Gurm Sunny, Wagner Ben, Hayward Joseph E., Fang Qiyin, “Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model,” Frontiers in Physics, 7: 192, 2019, doi.org/10.3389/fphy.2019.00192 (Open Access)
Jessica Kun, Marek Smieja, Bo Xiong, Leyla Soleymani, Qiyin Fang, “The Use of Motion Analysis as Particle Biomarkers in Lensless Optofluidic Projection Imaging for Point of Care Urine Analysis,” Scientific Reports 9, 17255, 2019, doi.org/10.1038/s41598-019-53477-8 (Open Access)
Eric Mahoney, Huan-Huan Hsu, Fei Du, Bo Xiong, P. Ravi Selvaganapathy, and Qiyin Fang, “Optofluidic Dissolved Oxygen Sensing With Sensitivity Enhancement Through Multiple Reflections,” IEEE Sensors 19(22): 10452-10460, 2019, doi.org/10.1109/JSEN.2019.2932414 (online)
Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, “Cross-talk reduction in a multiplexed synchroscan streak camera with simultaneous calibration,” Optics Express 27: 22602-22614, 2019, doi.org/10.1364/OE.27.022602 (Open Access)
Sinead Dufour, Donna Fedorkow, Jessica Kun, Shirley S.X. Deng, & Qiyin Fang, “Exploring the Impact of a Mobile Health Solution for Postpartum Pelvic Floor Muscle Training: Pilot Randomized Controlled Feasibility Study.” JMIR MHealth and UHealth, 7(7): e12587, 2019, doi.org/10.2196/12587 (Open Access)
Eric Mahoney, Colleen Chau, Qiyin Fang, “Experiential learning of data acquisition and sensor networks with a cloud computing platform,” Proc. SPIE 11143, Fifteenth Conference on Education and Training in Optics and Photonics: ETOP 2019, 111433X, 2 July 2019, doi.org/10.1117/12.2535399 (Open Access);
Henry Y.-H. Siu, B. Delleman, J. Langevin, Dee Mangin, Michelle Howard, Qiyin Fang, David Price, David Chan, “Demonstrating a Technology-Mediated Intervention to Support Medication Adherence in Community-Dwelling Older Adults in Primary Care: A Feasibility Study.” Gerontology and Geriatric Medicine, 5:1-11, 2019, doi.org/10.1177/2333721419845179 (online)
Fahad Aljekhedab, Wenbin Zhang, Harold K. Haugen, Gregory R. Wohl, Munir M. El-Desouki, Qiyin Fang, “Influence of environmental conditions in bovine bone ablation by ultrafast laser,” Journal of Biophotonics, 12(6): e201800293, 2019; doi.org/10.1002/jbio.201800293(online)
Ramy Abdlaty, Lilian Doerwald-Munoz, Ali Madooei, Samir Sahli, Shu-Chi Allison Yeh, Josiane Zerubia, Raimond K. W. Wong, Joseph E.Hayward, Thomas J. Farrell, Qiyin Fang, “Hyperspectral Imaging and Classification for Grading Skin Erythema,” Frontiers in Physics, 6, 72, 2018, DOI:10.3389/fphy.2018.00072(Open access)
S. C. Goh, Y. Luan, X.g Wang, H. Du, C. Chau, H. E. Schellhorn, J. L. Brash, H. Chen, and Q. Fang, “Polydopamine-polyethylene glycol-albumin antifouling coatings on multiple substrates,” Journal of Materials Chemistry B, 6, 940-949, 2018 (Online)
R. Abdlaty, J. Orepoulos, P. Sinclair, R. Berman, and Q. Fang, “High throughput AOTF hyperspectral imager for randomly polarized light,” Photonics, invited paper, 5(1), 3, 2018 (Open Access)
N. Shalaby, A. Al-Ebraheem, D. Le, S. Cornacchi, Q. Fang, T. Farrell, P. Lovrics, G. Gohla, S. Reid, N. Hodgson, M. Farquharson, “Time-Resolved Fluorescence (TRF) and Diffuse Reflectance Spectroscopy (DRS) for Margin Analysis in Breast Cancer,” Lasers in Surgery and Medicine,50(3):236–245, 2018.
V. N. D. Le, J. Provias, N. Murty, M. S. Patterson, Z. Nie, J. E. Hayward, T. Farrell , W. McMillan, W. Zhang, Q. Fang, “Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties,” Journal of Biomedical Optics, 22(2):027002, 2017
A. Tsikouras, P. Peronio, I. Rech, N. Hirmiz, M. J. Deen, and Q. Fang, “Characterization of SPAD Array for Multifocal High-Content Screening Applications,” Photonics, 3(4):56, 2016. (Open Access)
Z. Nie, V.N. Le, D. Cappon, J. Provias, N. Murty, J. E. Hayward, T. J. Farrell, M. S. Patterson, W. McMillan, Q. Fang, “Integrated Time-resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin,” IEEE Selected Topics in Quantum Electronics, 22(3): 6802109, 2016
V. N. D. Le, M. S. Patterson, T. J. Farrell, J. E. Hayward, Q. Fang, “Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence,” Journal of Biomedical Optics 20(12), 127003, 2015
A. Tsikouras, R. Berman, D. W. Andrews and Q. Fang, “High-speed multifocal array scanning using refractive window tilting,” Biomedical Optics Express 6, 3737-3757, 2015. (Open Access)
S. Sahli, R. C. C. Wang, A. Murthy, D. Armstrong, M. J. Deen, and Q. Fang, “a 360 degree side view endoscope for lower GI tract mapping,” Physics in Canada, 75(1): 18-20, 2015
S-C. A. Yeh, C. S.N. Ling, D. W. Andrews, M. S. Patterson, K. R. Diamond, J. E. Hayward, D. Armstrong, and Q. Fang, “5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015.
S-C. A. Yeh, S. Sahli, D. W. Andrews, M. S. Patterson, D. Armstrong, J. Provias, and Q. Fang, “5-ALA induced PpIX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015.
S-C. A. Yeh, M. S. Patterson, J. E. Hayward, and Q. Fang, “Time-Resolved Fluorescence in Photodynamic Therapy,” Photonics, 1(4): 530-564, 2014. (Open Access)
V. N. D. Le, Z. Nie, J. E. Hayward, T. J. Farrell, and Q. Fang, “Measurements of extrinsic fluorescence in Intralipid and polystyrene microspheres,” Biomedical Optics Express, 5(8): 2726-2735, 2014. (Open Access)
Z. Nie, R. An, J. E. Hayward, T. J. Farrell, Q. Fang, “Hyperspectral Fluorescence Lifetime Imaging for Optical Biopsy,” Journal of Biomedical Optics 18(9):096001, 2013
R. An, G. W. Khadar, E. I. Wilk, B. Emigh, H. R. Haugen, G. R. Wohl, B. Dunlop, M. Anvari, J. E. Hayward, and Q. Fang, “Ultrafast laser ablation and machining large size structures on porcine bone,” Journal of Biomedical Optics 18 (7):070504, 2013. (Open Access)
Z. Li, M. J. Deen, Q. Fang, and P.R. Selvaganapathy, “Design of a Flat field Concave Grating Based Micro‐Raman Spectrometer for Environmental Applications,” Applied Optics, 51(28):6855-6863, 2012
S. A. Yeh, K. R. Diamond, M. S. Patterson, Z. Nie, J. E. Hayward, and Q. Fang, “Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy,” Theranostics, 2(9): 817-826, 2012. (Open Access).
A. Tsikouras, J. Ning, S. Ng, R. Berman, D. W. Andrews, and Q. Fang, “Streak camera crosstalk reduction using a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012
B. Emigh, R. An, E. M. Hsu, T. H. R. Crawford, H. R. Haugen, G. R. Wohl, J. E. Hayward, and Q. Fang, “Porcine cortical bone ablation by ultrashort pulsed laser irradiation,” Journal of Biomedical Optics, 17(2):028001, 2012
R. W. K. Leung, S-C A. Yeh, and Q. Fang, “Effects of incomplete decay in fluorescence lifetime estimation,” Biomedical Optics Express 2(9):2517–2531, 2011. (Open Access)
R. C. C. Wang, M. J. Deen, D. Armstrong, and Q. Fang, “development of a catadioptric endoscope objective with forward and side views,” Journal of Biomedical Optics, 16(6):066015, 2011.
M. El-Desouki., D. Palubiak, M. J. Deen, Q. Fang, O. Marinov, “A novel, high-dynamic range, high-speed, and high sensibility CMOS imager using time-domain single-photon counting and avalanche photodiodes,” IEEE Sensors Journal, 11(4): 1078-1083, 2011.
Y. Yuan, J-Y. Hwang, M. Krishnamoorthy, J. Ning, Y. Zhang, K. Ye, R. C. Wang, M. J. Deen, Q. Fang, “A high throughput AOTF-based time-resolved fluorescence spectrometer for optical biopsy,” Optics Letters, 34(7): 1132-1134, 2009
L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J-H. Qiao, J. D. Baker, J. A. Freischlag, M. C. Fishbein, “Detection of Rupture-Prone Atherosclerotic Plaques by Time-Resolved Laser Induced Fluorescence Spectroscopy,” Atherosclerosis, Vol. 204(1): 156-164, 2009
M. ElDesouki, M. Jamal Deen, Qiyin Fang, Louis W. C. Liu, Frances Tse and David Armstrong, “CMOS Image Sensors for High Speed Applications,” Sensors, 9: 430-444, 2009
Y. Yuan, T. Papaioannou, Q. Fang, “Single shot acquisition of time-resolved fluorescence spectra using a multiple delay optical fiber bundle,” Optics Letters, 33(8): 791-793, 2008
J. A. Russell, K. R. Diamond, T. Collins, H. F. Tiedje, J. E. Hayward, T. J. Farrell, M. S. Patterson, Q. Fang, “Characterization of Fluorescence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells using Single and Two-photon Excitation,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 158-166, 2008
M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 226-234, 2008
N. Faramarzpour, M. M. El-Desouki, M. J. Deen, Q. Fang, S. Shirani and L. W-C. Liu, “CMOS Imaging for Biomedical Applications,” IEEE Potentials, May/June: 31-36, 2008
L. Marcu, Q. Fang, J. A. Jo, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, J. A. Freischlag M. C. Fishbein,. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005.
Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, “Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics,” Review of Scientific Instrument, Vol. 75(1): 151-162, 2004.
T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, and L. Marcu, “Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm,” Applied Optics, Vol. 43(14): 2846-2860, 2004.
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Qiyin Fang is currently a Professor at McMaster University.
Prior to joining McMaster, Dr. Fang was with the Minimally Invasive Surgical Technology Institute of Cedars-Sinai Medical Center in Los Angeles. Dr. Fang did graduate studies in North Carolina and undergraduate studies in Tianjin, China.
BSc. Physics, Nankai University
MASc. Applied Physics, East Carolina University
PhD. Biomedical Physics, East Carolina University
|_ENG PHYS 709 / BIOMED 707 (not offered 2023-24) Graduate||Advanced Topics in Biophotonics||
Prof. Qiyin Fang
|ENGPHYS 4I03 Technical Elective||Introduction to Biophotonics||
Prof. Qiyin Fang
|BIOMED 707/ENG PHYS 709 (not offered 2023-24) Graduate||Advanced Topics in Biophotonics||
Prof. Qiyin Fang
|IBEHS 4F04 Undergraduate||Biomedical Instrumentation and Measurement||
Prof. Qiyin Fang
|IBEHS 3P04 Undergraduate||Health Solutions Design Projects III: Analysis and Decision Making||
Prof. Qiyin Fang
|ENGPHYS 4US2 Undergraduate||Smart Systems Design & Implementation Laboratory||
Prof. Qiyin Fang