Professor
Department of Electrical & Computer Engineering
Professor
McMaster School of Biomedical Engineering
My work focuses on assessment of normal and diseased tissue microstructure and the resultant modulation of tissue metabolism using medical imaging technologies. A great deal of my research involves MRI and in vivo nuclear magnetic resonance (NMR) spectroscopy. However, more recently I have focused on applications of multimodal techniques, or the fusion of MRI with EEG, EMG, ultrasound and other imaging methods. Overall I am interested in developing more comprehensive and diagnostically useful disease imaging protocols for evaluation of anatomic, metabolic and functional characteristics of healthy and abnormal tissues.
Dr. Noseworthy was the Co-Director of the McMaster School of Biomedical Engineering from 2010 to 2020.
He is also Special Professional Staff in Radiology and Nuclear Medicine, and Director of Medical Imaging Physics and Engineering at St. Joseph’s Healthcare
Weber AM, Soreni N, Noseworthy MD. (2014)
MAGN RESON MATER PHY (MAGMA). 27(4):291-301
This paper was key in showing how the brain temporal complexity can decrease with intoxication
Fortuna JJ, Elzibak A, Fan Z, MacGregor J, Noseworthy MD. (2012)
J. CHEMOMETRICS 26:170-179
Paper won an international award. Because of the dual input function nature of the liver an appropriate model was difficult to elucidate. The multivariate approach was successful as we didn’t have to rely on an a priori model
Warsi MA, Molloy W, Noseworthy MD. (2012)
MAGN RESON MATER PHY (MAGMA). 25:335-344
The brain is a complex system. Here we showed how complexity decreases in a disease such as Alzheimer’s
Fatemi-Ardekani A, Boylan C, Noseworthy MD. (2009)
MEDICAL PHYSICS 36:5429-5436
This important paper shows how breast calcium can be visualized using MRI
Wardlaw G, Wong R, Noseworthy MD. (2008)
PHYSICA MEDICA 24:87-91
Here we showed a different type of contrast based on temporal complexity of blood oxygenation in tumours
Chevrier A, Noseworthy MD, Schachar R. (2007)
HUMAN BRAIN MAPPING 28:1347-1358
This work showed how locations of motor response, error and executive function could all be teased apart from one task
Bulte DP, Alfonsi J, Bells S, Noseworthy MD. (2006)
J. MAGN. RESON. IMAG. 24:886-890
This work showed how caffeine and antihistamines affected fast and slow twitch muscles
Zaraiskaya T, Kumbhare D, Noseworthy MD. (2006)
J. MAGN. RESON. IMAG. 24:402-408
This was the first clinical musculoskeletal application of DTI
Oakden WK, Noseworthy MD. (2005)
J. COMP. ASST. TOMOGR 29:136-139.
This work showed how propylene glycol, a pharmaceutical humectant, can be mistaken for lactate in the brain
Attenuation of brain BOLD response following lipid ingestion
HUMAN BRAIN MAPPING 20:116-121
We showed how an acute high fat diet can reduce BOLD MRI contrast in a simple motor task
Noseworthy MD, Ackerley C, Qi X, Wright GA. (2002)
ACAD. RADIOL. 9(SUPPL. 2):S514-S518
This work showed how gadolinium based contrast agents (GBCAs) get inside microvascular endothelial cells. This has now become a key issue surrounding the safety of these agents.
Dr. Noseworthy received a M.Sc. from the University of Guelph for work in the evaluation of anaesthetic hepatotoxicity using nuclear magnetic resonance imaging (MRI) and in vivo 31P-NMR. Obtained a PhD from University of Guelph (1997) specializing in applications of MRI/NMR, biochemical assays and electron paramagnetic resonance (EPR) methods to assess free radical induced brain damage. From 1997-1999 was a postdoctoral fellow in Imaging Physics, Sunnybrook Health Sciences Centre working on the evaluation of tissue microvasculature through development of correlative MRI and energy dispersive X-ray microanalysis (EDXS). From January 2000 to August 2003 worked as a MRI physicist at The Hospital for Sick Children, Toronto, and Assistant Professor in Medical Biophysics and Medical Imaging, University of Toronto. Moved to St. Joseph’s Healthcare and Brain-Body Institute, McMaster University in August 2003. Following 3 years as an Assistant Professor in Radiology and Medical Physics at McMaster University, Dr. Noseworthy attained a tenure-track position in Electrical & Computer Engineering at McMaster University, where he currently resides as a full professor. His research interests include the assessment of tissue microstructure and metabolism using magnetic resonance imaging (MRI) and multinuclear in vivo nuclear magnetic resonance (NMR) spectroscopic techniques, and the application of complex systems mathematics and machine learning to medical image analysis. Dr. Noseworthy is a member of the Professional Engineers of Ontario (PEO), Institute of Electrical and Electronics Engineers (IEEE), International Society for Magnetic Resonance in Medicine (ISMRM) and European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).
P.Eng. (L.E.L)
President’s Award for Excellence in Graduate Supervision (McMaster University, 2013)
| Code | Title | Instructor | Outline | Info |
|---|---|---|---|---|
| ELECENG 4BF4 Technical Elective | Advanced Medical Imaging (Not Offered 2021-2022) |
Dr. Michael Noseworthy |
Outline | More |
| BIOMED 765/MEDSCI 765 Graduate | Advanced Functional Brain Imaging |
Dr. Michael Noseworthy |
Outline | More |
| BIOMED 705 Graduate | Medical Imaging for Physical Scientists |
Dr. Michael Noseworthy |
Outline | More |
| BIOMED 6BC3 / ECE 6BC3 Graduate | Modeling of Biological Systems |
Dr. Michael Noseworthy |
Outline | More |
| ECE 780 Graduate | Medical Imaging Systems II |
Dr. Michael Noseworthy |
Outline | More |
| ECE 6BC3 Graduate | Modeling of Biological Systems |
Dr. Michael Noseworthy |
Outline | More |
| ELECENG 4BF4 Undergraduate | Advanced Medical Imaging |
Dr. Michael Noseworthy |
Outline | More |
