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Prof. Qiyin Fang

Professor and Canada Research Chair in Biophotonics

Department of Engineering Physics

Associate Member

Department of Electrical & Computer Engineering

Associate Member

School of Interdisciplinary Science

Expertise:
biophotonics, microscopy, fluorescence spectroscopy & imaging, intelligent sensing for point-of-care, aging-in-place, & environmental monitoring
Areas of Specialization:
Research Clusters:
Email:
Office:
ETB 405
Phone:
+1 905.525.9140 x 24227
Lab:
ETB 431

Overview

Currently Accepting Graduate Students

Biophotonics is a fast growing interdisciplinary field that concentrates on applying physical, chemical and engineering advances to biological and medical challenges.

Research Interests: 
Dr. Fang works on the development of optical spectroscopy and imaging systems for biomedical and environmental applications. His recent research projects include: multimodality optical biopsy techniques for real-time clinical diagnosis and guided therapy, optical endoscope designs for gastrointestinal (GI) cancer screening, photodynamic therapy (PDT) photosensitizer uptake and dosimetry, fluorescence lifetime imaging microscopy (FLIM) technologies for high content screening; ultrafast laser micromachining for medical implants; miniaturized optical sensors for water quality monitoring, and optical sensing and imaging technologies for smart home and aging research.

 

Dr. Fang is a member of:

He is also an Associate Member of:

  • Department of Electrical and Computer Engineering
  • School of Interdisciplinary Sciences

Education

BSc. Physics, Nankai University

MASc. Applied Physics, East Carolina University

PhD. Biomedical Physics, East Carolina University

Did you know…

Dr. Fang is the Canada Research Chair in Biophotonics and is cross-appointed with the School of Biomedical Engineering

Dr. Fang is a senior member and visiting lecturer of SPIE

Biography

Qiyin Fang is currently a Professor at McMaster University and held the Canada Research Chair in Biophotonics (Tier II) between 2005-2016. 

Prior to joining McMaster, Dr. Fang was with the Minimally Invasive Surgical Technology Institute of Cedars-Sinai Medical Center in Los Angeles. Dr. Fang obtained his graduate degrees from North Carolina and his undergraduate degree from Tianjin, China.  

Publications

Recent

  • V. N. D. Le, J. Provias, N. Murty, M. S. Patterson, Z. Nie, J. E. Hayward, T. Farrell , W. McMillan, W. Zhang, Q. Fang, “Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties,” Journal of Biomedical Optics, 22(2):027002, 2017
  • A. Tsikouras, P. Peronio, I. Rech, N. Hirmiz, M. J. Deen, and Q. Fang, “Characterization of SPAD Array for Multifocal High-Content Screening Applications,” Photonics, 3(4):56, 2016.
  • Z. Nie, V.N. Le, D. Cappon, J. Provias, N. Murty, J. E. Hayward, T. J. Farrell, M. S. Patterson, W. McMillan, Q. Fang, “Integrated Time-resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin,” IEEE Selected Topics in Quantum Electronics, 22(3): 6802109, 2016
  • V. N. D. Le, M. S. Patterson, T. J. Farrell, J. E. Hayward, Q. Fang, “Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence,” Journal of Biomedical Optics 20(12), 127003, 2015
  • A. Tsikouras, R. Berman, D. W. Andrews and Q. Fang, “High-speed multifocal array scanning using refractive window tilting,” Biomedical Optics Express 6, 3737-3757, 2015
  • S. Sahli, R. C. C. Wang, A. Murthy, D. Armstrong, M. J. Deen, and Q. Fang, “a 360 degree side view endoscope for lower GI tract mapping,” Physics in Canada, 75(1): 18-20, 2015
  • S-C. A. Yeh, C. S.N. Ling, D. W. Andrews, M. S. Patterson, K. R. Diamond, J. E. Hayward, D. Armstrong, and Q. Fang, “5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015.
  • S-C. A. Yeh, S. Sahli, D. W. Andrews, M. S. Patterson, D. Armstrong, J. Provias, and Q. Fang, “5-ALA induced PpIX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015.
  • S-C. A. Yeh, M. S. Patterson, J. E. Hayward, and Q. Fang, “Time-Resolved Fluorescence in Photodynamic Therapy,” Photonics, 1(4): 530-564, 2014
  • V. N. D. Le, Z. Nie, J. E. Hayward, T. J. Farrell, and Q. Fang, “Measurements of extrinsic fluorescence in Intralipid and polystyrene microspheres,” Biomedical Optics Express, 5(8): 2726-2735, 2014
  • Z. Nie, R. An, J. E. Hayward, T. J. Farrell, Q. Fang, “Hyperspectral Fluorescence Lifetime Imaging for Optical Biopsy,” Journal of Biomedical Optics 18(9):096001, 2013
  • R. An, G. W. Khadar, E. I. Wilk, B. Emigh, H. R. Haugen, G. R. Wohl, B. Dunlop, M. Anvari, J. E. Hayward, and Q. Fang, “Ultrafast laser ablation and machining large size structures on porcine bone,” Journal of Biomedical Optics 18 (7):070504, 2013
  • Z. Li, M. J. Deen, Q. Fang, and P.R. Selvaganapathy, “Design of a Flat field Concave Grating Based Micro‐Raman Spectrometer for Environmental Applications,” Applied Optics, 51(28):6855-6863, 2012
  • S. A. Yeh, K. R. Diamond, M. S. Patterson, Z. Nie, J. E. Hayward, and Q. Fang, “Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy,” Theranostics, 2(9): 817-826, 2012
  • A. Tsikouras, J. Ning, S. Ng, R. Berman, D. W. Andrews, and Q. Fang, “Streak camera crosstalk reduction using  a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012
  • B. Emigh, R. An, E. M. Hsu, T. H. R. Crawford, H. R. Haugen, G. R. Wohl, J. E. Hayward, and Q. Fang, “Porcine cortical bone ablation by ultrashort pulsed laser irradiation,” Journal of Biomedical Optics, 17(2):028001, 2012
  • R. W. K. Leung, S-C A. Yeh, and Q. Fang, “Effects of incomplete decay in fluorescence lifetime estimation,” Biomedical Optics Express 2(9):2517–2531, 2011
  • R. C. C. Wang, M. J. Deen, D. Armstrong, and Q. Fang, “development of a catadioptric endoscope objective with forward and side views,” Journal of Biomedical Optics, 16(6):066015, 2011.
  • M. El-Desouki., D. Palubiak, M. J. Deen, Q. Fang, O. Marinov, “A novel, high-dynamic range, high-speed, and high sensitibility CMOS imager using time-domain single-photon counting and avalanche photodiodes,” IEEE Sensors Journal, 11(4): 1078-1083, 2011.
  • Y. Yuan, J-Y. Hwang, M. Krishnamoorthy, J. Ning, Y. Zhang, K. Ye, R. C. Wang, M. J. Deen, Q. Fang, “A high throughput AOTF-based time-resolved fluorescence spectrometer for optical biopsy,” Optics Letters, 34(7): 1132-1134, 2009
  • L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J-H. Qiao, J. D. Baker, J. A. Freischlag, M. C. Fishbein, “Detection of Rupture-Prone Atherosclerotic Plaques by Time-Resolved Laser Induced Fluorescence Spectroscopy,” Atherosclerosis, Vol. 204(1): 156-164, 2009
  • M. ElDesouki, M. Jamal Deen, Qiyin Fang, Louis W. C. Liu, Frances Tse and David Armstrong, “CMOS Image Sensors for High Speed Applications,” Sensors, 9: 430-444, 2009
  • Y. Yuan, T. Papaioannou, Q. Fang, “Single shot acquisition of time-resolved fluorescence spectra using a multiple delay optical fiber bundle,” Optics Letters, 33(8): 791-793, 2008
  • J. A. Russell, K. R. Diamond, T. Collins, H. F. Tiedje, J. E. Hayward, T. J. Farrell, M. S. Patterson, Q. Fang, “Characterization of Fluorescence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells using Single and Two-photon Excitation,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 158-166, 2008
  • M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 226-234, 2008
  • N. Faramarzpour, M. M. El-Desouki, M. J. Deen, Q. Fang, S. Shirani and L. W-C. Liu, “CMOS Imaging for Biomedical Applications,” IEEE Potentials, May/June: 31-36, 2008
  • L. Marcu, Q. Fang, J. A. Jo, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, J. A. Freischlag M. C. Fishbein,. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005. 
  • Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, “Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics,” Review of Scientific Instrument, Vol. 75(1): 151-162, 2004. 
  • T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, and L. Marcu, “Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm,” Applied Optics, Vol. 43(14): 2846-2860, 2004. 

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