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Dr. Zeinab Hosseini-Doust

Assistant Professor

Department of Chemical Engineering

Expertise:
Bacteriophage Biotechnology, Bacterial Biofilms, Phage Antimicrobials, Targeted Antimicrobial Delivery, Biohybrid Systems
Areas of Specialization:
Research Clusters:

Overview

The aim of my lab is to design engineering solutions for tackling infectious disease. Our approach is based on the biohybrids design: we integrate biological entities (particularly bacteriophages and bacteriophage derived tools) along with synthetic nanoparticles, biopolymers, and hydrogels, to develop novel materials and devices that address challenges in human health and the health of our environment. The biohybrids design concept spans across multiple disciplines and integrates engineering with molecular biology, materials science, and chemistry. To learn more, visit the lab website and follow us on Instagram. 

Research Platforms

Platform A: Alternative antimicrobials

The main focus of this class of projects is on bacteriophages (or phage for short) and phage lysins.  A bacteriophage is a virus that infects bacteria. We isolate phage form clinical and environmental samples and design bacteriophage antimicrobials for treating difficult-to-treat infections and bacterial biofilms. We further investigate the interaction of such therapies with the host microbiome.  

Platform B: Targeted, nano-drug delivery solutions

Targeting drugs directly to the site of infection with the potential to include other active agents to disrupt the biofilm matrix would increase the efficacy of treatment for invasive bacteria infections.  We focus on developing smart nanoparticles and bioactive materials, with controlled release.

Platform C: Bioactive coatings and hydrogels

We combine biological colloids with non-biological colloids and surfaces to form materials and interfaces that are bioactive (exhibit specific interaction with one or a range of desired biomarkers) and multifunctional (e.g., electrically conductive, antibacterial, photoactive, repellent, etc.) to form multifunctional, bioactive, soft biomaterial.

Education

  • PDF, Max Planck Institute for Intelligent systems, Germany, 2016
  • Ph.D., McGill University, Montreal, Canada, 2013
  • B.Sc., Sharif University of Technology, Tehran, Iran, 2003

Did you know…

Phages are viruses that infect bacteria. They were discovered 100 years ago and have been used as natural antibacterials ever since. With the rising crisis of antibiotic resistance, phages could be our hope for a post-antibiotic era. 
Our lab works on developing engineering solutions to global health problems using phages. If you want to learn more about phages, visit our lab website: https://www.biohybridslab.com/resources
 
For Prospective Students: We welcome applications from highly motivated students that share our passion for science and curiosity about phages and their applications. If you want to join my lab as a graduate student or a postdoc, please contact me directly with your latest transcripts and an up-to-date CV. Every year our lab hosts numerous NSERC-USRA and undergraduate thesis students. If you are an undergraduate student looking to do research for credit or to satisfy your own curiosity, do not hesitate to contact me with your latest transcripts and CV. 
 
For postdocs: Currently, we welcome applications from postdoctoral applicants that hold a major Canadian or international fellowship.
 
For potential Academic or Industrial Collaborators: Please see our lab website to learn more about our research expertise (https://www.biohybridslab.com/publications) and also about the equipment and unique facilities we can offer as part of a collaborative project: https://www.biohybridslab.com/facilities

Biography

I am a chemical engineer, fascinated by microbiology. For the past 10 years, I have been working on employing the intelligence of biological systems (specifically bacteriophages and bacteria) to tackle the outstanding challenges related to human health. I joined the Chemical Engineering Department at McMaster in July 2016. I am also an associate member at the Micheal DeGroote Institute for Infectious Disease ResearchThe Farncombe Institute and the School of Biomedical Engineering.

Publications

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