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Dr. Raja Ghosh

Professor

Department of Chemical Engineering

Expertise:
bioseparation using ultrafiltration; bioseparation using membrane chromatography; biomimetic membranes
Areas of Specialization:
Research Clusters:
Email:
Office:
JHE A408
Phone:
+1 905.525.9140 x 27415

Overview

Research Interests

Membrane chromatography

Design and development of novel membrane chromatography devices, development of novel membranes and processes for biopharmaceutical applications.

Bioseparations process development
Development of efficient, scalable, high-resolution purification processes bio-pharmaceuticals such as monoclonal antibodies and PEGylated proteins.

Membrane bioreactors

Development of novel bioreactor system for diverse applications such as enzymatic catalysis, protein PEGylation and mammalian cell culture.

Biopharmaceutical product stabilization and assessment

Development of efficient method for detecting and analyzing antibody aggregates and stabilizing therapeutic proteins.

Education

  • D.Phil.Chemical Engineering, University of Oxford (1999)

Publications

Selected

Madadkar, U. Umatheva, G. Hale, Y. Durocher, R. Ghosh*

Ultrafast separation and analysis of monoclonal antibody aggregates using membrane chromatography

Analytical Chemistry, 89 (2017) 4716-4720

Recent

Updated: Publication List October 2017 

Refereed Journal Papers

* Corresponding author

  1. Ghosh*, G. Chen, Mathematical modelling and evaluation of performance of cuboid packed-bed devices for chromatographic separations, Journal of Chromatography A, 1515 (2017) 138-145.
  2. Madadkar, U. Umatheva, G. Hale, Y. Durocher, R. Ghosh*, Ultrafast separation and analysis of monoclonal antibody aggregates using membrane chromatography, Analytical Chemistry, 89 (2017) 4716-4720.
  3. Shahid, R. Ghosh*, Dewatering of microalgae suspension using air-sparged ultrafiltration, Separation Science and Technology, 52 (2017) 344-351.
  4. Madadkar, R. Sadavarte, M. Butler, Y. Durocher, R. Ghosh*, Preparative separation of monoclonal antibody aggregates by cation exchange laterally-fed membrane chromatography. Journal of Chromatography B, 1055-1056 (2017) 158-164.
  5. Xu, R. Peng, X. Chen, R. Ghosh, H.P.V. Rupasinghe*, Isolation of flavonoids from apple peel using graphene oxide cotton fiber, Natural Product Research, 2017 (2017) 1-5.
  6. S. Kazemi, L. Boivin, S.M. Yoo, R. Ghosh, D.R. Latulippe*, Elucidation of filtration performance of hollow-fibre membranes via a high-throughput screening platform, Journal of Membrane Science, 535 (2017) 241-249.
  7. Sadavarte, C.D.M. Filipe, R. Ghosh*, Recovery of functionally-active protein from inclusion bodies using a thermal-cycling method, Biotechnology Progress, 33 (2017) 133-139.
  8. Peng, X. Chen*, R. Ghosh*, Preparation of graphene oxide-cotton fiber composite adsorbent and its application for the purification of polyphenols from pomegranate peel extract, Separation and Purification Technology, 174 (2017) 561-569.
  9. Peng, Q. Wu, X. Chen*, R. Ghosh*, Purification of danshensu from Salvia miltiorrhiza extract using graphene oxide based composite adsorbent, Industrial and Engineering Chemistry Research (2017) accepted.
  10. Qin, A.U. Alam, S. Pan, M.M.R. Howlader, R. Ghosh, N.X. Hu, H. Jin, S. Dong, C.H. Chen, M.J. Deen*, Integrated water quality monitoring system with pH, free chlorine, and temperature sensors, Sensors and Actuators B: Chemical, (2017) accepted.

Book Chapters 

  1. R. Ghosh, Ultrafiltration based protein bioseparation, in Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applications (Editors: A. K. Pabby, A. M. Sastre and S. S. H. Rizvi), CRC Press ISBN-10: 0849395496 (2008).
  2. R. Ghosh, Application of ultrafiltration in the biopharmaceutical industry, in Advanced Membrane Technology and Applications (Editors: N. Li, A.G. Fane, W.S. Winston Ho, T. Matsuura), John Wiley and Sons ISBN: 978-0-471-73167-2 (2008).
  3. R. Ghosh, Protein bioseparation using membrane adsorbers: combining high-resolution with high-throughput, in Protein Production, Aggregation and Degradation in Recombinant Bacterial Factories (Editor: A. Villaverde), Research Signpost ISBN: 81-7736-110-4 (2002).
  4. K. Mohanty, R. Ghosh, Gas-sparged ultrafiltration: recent trends, applications and future challenges, in Handbook of Environmental Engineering vol. 13 (Editors: L.K. Wang, J.P. Chen, Y.T. Hung, N.K. Shammas), Humana Press ISBN: 1588299406 (2010).
  5. J.A. Shaeiwitz, J.D. Henry Jr, R. Ghosh, Bioseparations, ULLMANN Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH (2012).
  6. R. Ghosh, Application of membranes in biotechnology, Encyclopedia of Membrane Science and Technology, John Wiley and Sons (2013).
  7. R. Ghosh, Membrane chromatography: current applications, future opportunities, and challenges. Membrane Processing for Dairy Ingredient Separation, Ed. Hu, K., Dickson, J.M., Wiley (2015).
  8. R. Ghosh, Bioseparations using integrated membrane processes, Integrated Membrane Systems and Processes, Ed. A. Basile, C. Charcosset, Wiley (2016, in press)

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