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Heather

Dr. Heather Sheardown

Professor

Department of Chemical Engineering

Expertise:
biomaterials, tissue engineering, mathematical modeling of physiologic processes, ophthalmic drug delivery.
Areas of Specialization:
Research Clusters:
Email:
Office:
JHE 124A
Phone:
+1 905.525.9140 x 24794
LinkedIn

Overview

Active Research Initiatives

C20/20 - ORF

The Biomedical Engineering and Advanced Manufacturing (BEAM) project  

Past Research Initiatives

20/20 Network

 

Research Interests 

1) Drug delivery - Anterior Eye

2) Drug delivery - Posterior Eye

3) Contact Lens 

4) IOLs 

5) In Vivo Ocular Testing 

Education

  • B.Eng. McMaster University (1989)
  • Ph.D. University of Toronto (1995)

Biography

Dr. Sheardown holds a Tier 1 Canada Research Chair Ophthalmic Biomaterials and Drug Delivery Systems. She is an expert in drug delivery, contact lens materials, IOLs, polymer chemistry, and bioengineering in the ophthalmic space.  

Publications

Recent

 

  • Rastergari B, Zenali S, Sheardown H, Karbelaei-Heidari HR.  The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: synthesis, characterization and cytotoxicity studies.  Eur J Pharm Biopharm.  Submitted 2016. 
  • Xu F, Sheardown H, Hoare T.  Reactive electrospinning of degradable poly (oligoethylene glycol methacrylate) based nanofibrous hydrogel networks.  Chem Commun 52: 1451-1454 (2016).
  • Princz MA, Sask KN, Brash JL, Sheardown H.  Pre-activated heparinized crosslinked collagen matrices as improved blood contacting materials.  J Biomater Applications Submitted 2016.
  • Brunette I, Roberts CJ, Vidal F, Harissi-Dagher M, Lachaine J, Sheardown H, Durr GM, Proulx S, Griffith M.  Alternatives to native eye bank tissue for corneal stromal replacement.  Invited review.  Progress in Retinal and Eye Research In Press 2016.
  •  Zhang J, Muirhead B, Dodd M, Liu L, Mangiacotte N, Xu F, Hoare TR, Sheardown H.  An injectable hydrogel prepared using a PEG/Vitamin E copolymer facilitating aqueous driven gelation.  Biomacromolecules  17: 3648-3658 (2016)
  • Jamard M, Hoare TR, Sheardown H.  Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery.  J Trans Drug Delivery Res 6: 648-659 (2016).
  • Fawcett AS, Liu L, Prosperi-Porta G, Korogiannaki M, Sheardown H.  Natural polymers for ocular drug delivery.  Journal of Biomedical Engineering and Medical Devices.  Submitted 2016.
  • Fitzpatrick SD, Mazumder J, Baek D, Zhao X, Wang H, Fitzpatrick L, Boyd S, Sheardown H.  Optically transparent thermally gelling drug delivery scaffold for minimally invasive posterior segment drug delivery. Acta Biomaterialia Submitted 2016.
  • Lasowski F, Sheardown H.  Atropine and roscovitine release from model silicone hydrogels.  Optom Vis Sci. 93: 404-411 (2016)
  • Deng X, Korogiannaki M, Rastegari B, Zhang J, Chen M, Fu Q, Sheardown H, Filipe C, Hoare T.  ‘Click’ Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower Protein Adsorption ACS Applied Materials and Interfaces.  8: 22064-22073 (2016).
  • Prosperi-Porta G, Kedzior S, Muirhead B, Sheardown H.  Phenylboronic acid based polymeric micelles for mucoadhesive anterior segment ocular drug delivery Biomacromolecules  17:1449-1457 (2016).
  • Korogiannaki M, Guidi G, Jones L, Sheardown H.  Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials  J Biomater Appl 30:361-376 (2015)
  • Prosperi-Porta G, Muirhead B, Sheardown H.  Tunable release of ophthalmic therapeutics from injectable, resorbable, thermoresponsive copolymer scaffolds.  J Biomed Mater Res B doi: 10.1002/jbm.b.33501
  • Sheikholeslami P, Baek DS, Muirhead B, Wang H, Zhao H, Sivakumaran D Boyd S, Sheardown H, Hoare TR. Hydrophobically modified poly(vinyl pyrrolidone) as a physically associative, shear responsive ophthalmic hydrogel Exp Eye Res 137: 18-31 (2015).
  • Xu F, Sheardown H, Hoare TR.  Reactive Electrospinning of Degradable Poly (oligoethylene glycol methacrylate)-Based Nanofibrous Hydrogel Networks.  Chem Communications. 52: 1451-1454 (2016).
  • Rambarran T, Gonzaga F, Brook MA, Lasowksi F, Sheardown H.  Amphiphilic elastomers from metal free click crosslinking of PEG-grafted silicone surfactants.  J Polym Sci Part A: Polym Chem 53:1082-1093 (2015).

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