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Microfabricated tissues for medical discovery and therapy

Microfabricated tissues for medical discovery and therapy

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BSB 138

The rising cost of healthcare driven by the increasing expenditures in drug discovery and clinical treatments has become a significant burden to our society while the outcomes of care have not improved. To reverse this trend, the healthcare industry demands innovative biotech solutions that will disrupt the existing methods of care.

Overview

The rising cost of healthcare driven by the increasing expenditures in drug discovery and clinical treatments has become a significant burden to our society while the outcomes of care have not improved. To reverse this trend, the healthcare industry demands innovative biotech solutions that will disrupt the existing methods of care. The field of tissue engineering emerged nearly two decades ago promises to offer human tissues on demand. Realizing this ambitious goal will fundamentally transform modern medicine and change the way we approach drug discovery and clinical treatments. To this end, we strive to develop advanced biofabrication techniques integrated with insights from developmental biology to build human micro-tissue models for predictive drug discovery and to construct functional macro-tissues for tissue regeneration in patients. Microfabricated smart biomaterials can provide structural support and spatial control for tissue assembly resulting in tissue models or implantable tissues with realistic physiological functions. In this seminar, I will discuss the recent breakthroughs we have made in scaffold fabrication and how it resulted in several technologies for drug screening and tissue repair applications. Building on this progress, I will also discuss the path forward. Successful development of novel tissue assembly strategies will expand our toolbox to propel drug discoveries and clinical therapy towards greater precision, reduced translational costs, and improved efficacy.

Biography

Boyang Zhang is an Assistant Professor in the Department of Chemical Engineering at McMaster University. Boyang joined McMaster in July 2018. Previously, Dr. Zhang was a Banting Postdoctoral Fellow at University of Toronto and a co-founder of a start-up company, TARA Biosystems, where he developed the manufacturing process of BiowireTM plates for cardiotoxicity screening. Dr. Zhang obtained B.Sc. in Chemical and Biomolecular Engineering from Georgia Institute of Technology in 2010, and Ph.D. in Chemical Engineering and Applied Chemistry from University of Toronto in 2016. His research interest lies in the innovation of advanced biofabrication techniques integrated with insight from developmental biology to develop the next generation functional tissues for drug discovery and regenerative medicine.