Skip to main content
Upcoming Events:
Emerging organ models and organ printing for regenerative medicine

Emerging organ models and organ printing for regenerative medicine

Date & Time:
   Add All to Calendar
Location:

HSC – Farncombe Atrium

Khademhosseini Laboratory is a world-leading multidisciplinary research group at California NanoSystems Institute, University of California Los Angeles. Our team consists of various students and researchers from different backgrounds and nationalities, all aiming to push forward novel micro/nanoscaled technologies for the purpose of minimally invasive therapeutics. We have accumulated experience and expertise in biomaterials engineering, cell/tissue engineering, biofabrication, and organ-on-a-chip to facilitate technological translation from the lab to clinics for the better society.

Overview

Engineered materials that integrate advances in polymer chemistry, nanotechnology, and biological sciences have the potential to create powerful medical therapies. Our group aims to engineer tissue regenerative therapeutics using water-containing polymer networks called hydrogels that can regulate cell behavior. Specifically, we have developed photo-crosslinkable hybrid hydrogels that combine natural biomolecules with nanoparticles to regulate the chemical, biological, mechanical and electrical properties of gels. These functional scaffolds induce the differentiation of stem cells to desired cell types and direct the formation of vascularized heart or bone tissues. Since tissue function is highly dependent on architecture, we have also used microfabrication methods, such as microfluidics, photolithography, bioprinting, and molding, to regulate the architecture of these materials. We have employed these strategies to generate miniaturized tissues. To create tissue complexity, we have also developed directed assembly techniques to compile small tissue modules into larger constructs. It is anticipated that such approaches will lead to the development of next-generation regenerative therapeutics and biomedical devices.

Biography

Ali Khademhosseini, Ph.D.
Professor
Departments of Bioengineering, and Chemical and Biomolecular Engineering,
Henry Samueli School of Engineering and Applied Science at UCLA
Radiological Sciences, David Geffen School of Medicine at UCLA

Ali Khademhosseini is a Professor of Bioengineering, and Chemical and Biomolecular Engineering at UCLA Henry Samueli School of Engineering and Applied Science, and at the UCLA Radiological Sciences David Geffen School of Medicine. He is a director of the Center for Minimally Invasive Therapeutics (C-MIT) at UCLA. He is recognized as a leader in combining micro- and nano-engineering approaches with advanced biomaterials for regenerative medicine applications.  In particular, his laboratory has pioneered numerous technologies and materials for controlling the architecture and function of engineered vascularized tissues. He has authored ~550journal papers (H-index > 114, >47,000 citations) and 60 books/chapters.   In addition, he has delivered 300+ invited/keynote lectures.  Dr. Khademhosseini’s interdisciplinary research has been recognized by over 40 major national and international awards. He is a recipient of the Presidential Early Career Award for Scientists and Engineers, the highest honor given by the US government for early career investigators. In 2011, he received the Pioneers of Miniaturization Prize from the Royal Society of Chemistry (RSC) for his contribution to microscale tissue engineering and microfluidics.  In 2016, he received the Sr. Scientist Award of Tissue Engineering and Regenerative Medicine Society -Americas Chapter (TERMIS-AM), in 2017 he received the Clemson Award of the Society for Biomaterials and in 2018 he was honored by the Acta Biomaterialia Silver Medal (2018).  He is also a fellow of the American Institute of Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), Royal Society of Chemistry (RSC), Fellow of the Biomaterials Sciences and Engineering (FBSE) and American Association for the Advancement of Science (AAAS).  Currently he serves on the editorial board of numerous leading journals as well as an Associate Editor for ACS Nano (IF: 13.3) and a member of NIH BTSS study section.  He received his Ph.D. in bioengineering from MIT (2005), MASc in biomedical engineering (2001) and BASc in chemical engineering (1999) degrees from University of Toronto. Read more at http://www.tissueeng.net/.