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3D-printing and microfluidics for point-of-care diagnostics, tissue engineering and organ-on-a-chip

3D-printing and microfluidics for point-of-care diagnostics, tissue engineering and organ-on-a-chip

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BSB 106

My lab is exploring various facets of miniaturization and integration in biology and medicine, which includes the conception, engineering and utilization of novel micro and nanotechnologies for manipulating, stimulating and studying oligonucleotides, proteins, cells, and tissues.

Overview

3D printing is empowering many applications, and I will present the use of stereolithographic printing for 3 applications including capillary microfluidics, cell-cell and cell-hydrogel arrays and vascularization of brain organoids. Firstly, capillary microfluidics in microchannels will be discussed, and the development of advanced systems that we term capillaric circuits based on analogy to electronics, and modular assembly of components towards making complex circuits. The use of capillaric circuits for immunoassays, rapid diagnostic tests for measles vaccination, bacterial capture in urinary tract infection, and finally for testing blood coagulation by automating the currently labour intensive thrombogram, will be discussed. Secondly, 3D printed monolithic pin heads (MPH) along with a self-alignment method for printing multiple cell and hydrogels with super-precise alignment will be presented. MPH transfer liquids via capillary effects, and outperform other methods in their ability to print high viscosity solutions, and were used to print hydrogels with different viscosity and mechanical properties. Cell-hydrogel and cell-cell interactions between 6 different parental and organotypic cancer cells and their stroma were studied, as well as cell-hydrogel interaction, and analyzed by live imaging and automated cell tracking. Thirdly, preliminary results on the vascularization of minibrains using 3D printed molds will be presented. Time permitting, other research projects from the lab will be discussed.

Biography: David stayed as a visiting scientist at the National Metrology Institute of Japan in Tsukuba from 1997-98. He conducted his PhD research at the IBM Zurich Research Laboratory from 1999-2002. He then pursued his studies as a Post-doc first at IBM Zurich until 2004, and then one year at the Swiss Federal Institute of Technology in Zurich (ETH). David started as an assistant professor in the Biomedical Engineering Department of McGill University in 2005, was promoted to associate professor with tenure in 2011, and became a full professor in 2016. As of early 2018, David serves as departmental chair of the Biomedical Engineering Department at McGill University.